Vinblastine (sulfate) [143-67-9]
Referencia HY-13780-10mg
embalaje : 10mg
Marca : MedChemExpress
Vinblastine sulfate is a cytotoxic alkaloid used against various cancer types. Vinblastine sulfate inhibits the formation of microtubule and suppresses nAChR with an IC50 of 8.9 μM.
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Vinblastine sulfate Estructura química
No. CAS : 143-67-9
This product is a controlled substance and not for sale in your territory.
Based on 11 publication(s) in Google Scholar
Descripciòn |
Vinblastine sulfate is a cytotoxic alkaloid used against various cancer types. Vinblastine sulfate inhibits the formation of microtubule and suppresses nAChR with an IC50 of 8.9 μM. |
IC50 & Target |
IC50: 8.9 μM(nAChR)[1] |
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In Vitro |
Vinblastine does not depolymerize spindle microtubules, yet it powerfully blocks mitosis (for example, IC50 0.8 nM in HeLa cells) and cells die by apoptosis[2]. In NB4 cells, vinblastine produces alteration of p53 and DNA fragmentation. Vinblastine treatment has an antiproliferative effect via the induction of apoptosis producing Bax/Bcl-2 imbalance. Vinblastine treatment suppresses NFκB expression and depresses NFκB-DNA binding activity while maintaining JNK activation that subsequently results in apoptotic response through caspase-dependent pathway[3]. Vinblastine is found to trigger apoptosis as evidenced by the loss of mitochondrial membrane potential, the release of both cytochrome c and apoptosis inducing factor, activation of caspase-9 and 3, and cleavage of Poly (ADP-ribose)-Polymerase[4]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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In Vivo |
Vinblastine is a widely used anticancer drug with undesired side effects. Its conjugation with carrier molecules could be an efficient strategy to reduce these side effects[5]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Ensayo clínico |
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Peso molecular |
909.05 |
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Fòrmula |
C46H60N4O13S |
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No. CAS |
143-67-9 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
08[C@@]12C[C@@](C3=C(OC)C=C(N([C@]4(08)[C@@]56[C@]7(08)[C@](C=CCN7CC6)(CC)[C@@H](OC(C)=O)[C@@]4(C(OC)=O)O)C)C5=C3)(C(OC)=O)C(NC8=C9C=CC=C8)=C9CC[N@](C2)C[C@](O)(CC)C1.OS(=O)(O)=O |
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Structure Classification |
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Initial Source |
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Envío | Room temperature in continental US; may vary elsewhere. |
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Almacenamiento |
4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
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Solvente y solubilidad |
In Vitro:
H2O : 50 mg/mL (55.00 mM; Need ultrasonic) DMSO : ≥ 44 mg/mL (48.40 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) *"≥" means soluble, but saturation unknown. Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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Pureza y Documentación |
Purity: 99.04% |
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Referencias |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO / H2O | 1 mM | 1.1000 mL | 5.5002 mL | 11.0005 mL | 27.5012 mL |
5 mM | 0.2200 mL | 1.1000 mL | 2.2001 mL | 5.5002 mL | |
10 mM | 0.1100 mL | 0.5500 mL | 1.1000 mL | 2.7501 mL | |
15 mM | 0.0733 mL | 0.3667 mL | 0.7334 mL | 1.8334 mL | |
20 mM | 0.0550 mL | 0.2750 mL | 0.5500 mL | 1.3751 mL | |
25 mM | 0.0440 mL | 0.2200 mL | 0.4400 mL | 1.1000 mL | |
30 mM | 0.0367 mL | 0.1833 mL | 0.3667 mL | 0.9167 mL | |
40 mM | 0.0275 mL | 0.1375 mL | 0.2750 mL | 0.6875 mL | |
H2O | 50 mM | 0.0220 mL | 0.1100 mL | 0.2200 mL | 0.5500 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Vinblastine sulfate Related Classifications
- Cell Cycle/DNA Damage Cytoskeleton Autophagy
- Microtubule/Tubulin Autophagy