22(R)-Hydroxycholesterol

Biological Activity

22(R)-Hydroxycholesterol is an intermediate of the pregnenolone synthesis pathway from cholesterol. It has neuroprotective properties and protects the neurons against β-amyloid-induced cell death. 22(R)-Hydroxycholesterol acts as the ligand of liver X receptors that act as sensors of sterol concentration and regulates the fatty acid metabolism.

Chemical Information

Molecular Weight	402.65
Formula	C27H46O2
CAS Number	17954-98-2
Solubility (25°C)	Chloroform (Slightly) Methanol (Slightly)
Storage	Powder          -20°C   3 years ;  4°C   2 years In solvent       -80°C   6 months ;  -20°C   1 month

References

[1] Manisha Singh, et al. Cell Death Discov. 22(R)-hydroxycholesterol for dopaminergic neuronal specification of MSCs and amelioration of Parkinsonian symptoms in rats

[2] Hyunmi Kim, et al. Biochim Biophys Acta. 22(R)-hydroxycholesterol induces HuR-dependent MAP kinase phosphatase-1 expression via mGluR5-mediated Ca(2+)/PKCα signaling

[3] Jing-Min Wang, et al. Biochem Biophys Res Commun. 22(R)-hydroxycholesterol and pioglitazone synergistically decrease cholesterol ester via the PPARγ-LXRα-ABCA1 pathway in cholesterosis of the gallbladder

[4] Chih-Pin Chuu, et al. Anticancer Res. Antiproliferative effect of LXR agonists T0901317 and 22(R)-hydroxycholesterol on multiple human cancer cell lines

[5] Ruitang Deng, et al. J Pharmacol Exp Ther. Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor farsenoid X receptor but not liver X receptor