Our ABL2 break apart probe is designed to detect ABL2 translocations. The probe comes labeled in orange and green, but can be customized to meet your needs.
Gene Background: ABL2 belongs to the same gene family of Abelson nonreceptor tyrosine kinases as ABL1. It regulates actin rearrangement via phosphorylation of cytoskeleton-remodeling proteins, including MYH10, CTTN, and TUBB. ABL2 rearrangements have been identified in several leukemias, often resulting in fusions with ETV6.
Source: GeneCards.org
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
Gene Summary
This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
Gene Details
Gene Symbol: ABL2
Gene Name: ABL Proto-oncogene 2, Non-receptor Tyrosine Kinase
Chromosome: CHR1: 179068461-179198819
Locus: 1q25.2