Acalabrutinib

Cat# 440755-5mg

Size : 5mg

Marca : US Biological

Richiedere ulteriori informazioni

Contatta il distributore locale :


Telefono : +1 850 650 7790


440755 Acalabrutinib

Clone Type
Polyclonal
Grade
Highly Purified
Shipping Temp
RT
Storage Temp
4°C

Acalabrutinib, is an experimental anti-cancer drug and a selective Bruton's tyrosine kinase (BTK) inhibitor. This kinase transmits signals from B-cell Receptor (BCR), and thus any genetic BTK mutation causes B-Cell immunodeficiency. Therefore, BTK inhibitors targeting B-cell signaling has shown great promise for the treatment of chronic lymphocytic leukemia (CLL).||Synonyms:|4-[8-amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1- yl]-N-2-pyridinylbenzamide; ACP 196||CAS No:|1420477-60-6||Molecular Formula:|C26H23N7O2||Molecular Weight:|465.51||Purity (HPLC):|≥98%||Appearance:|Light yellow to yellow solid||Solubility:|DMSO (Slightly), Methanol (Slightly)||NMR, CNMR, LC-MS:|Conforms to reference||Storage and Stability:|May be stored at RT for short-term only. Long-term storage is recommended at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Applications
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. ||Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.
References
1. Burd, J.C., Harrington, B., O'Brien, S., et al. Acalabrutinib (ACP-196) in relapsed chronic lymphocytic leukemia. N. Engl. J. Med. 374(4), 323-332 (2016).