Amyloid Beta Peptide 1-42 (OVA - Conjugated)
Cat# OOCD00250-200UG
Size : 200ug
Marca : Aviva Systems Biology
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Amyloid Beta Peptide 1-42 (OVA - Conjugated) (OOCD00250)
| Datasheets/Manuals | Printable datasheet for Amyloid Beta Peptide 1-42 (OVA - Conjugated) (OOCD00250) |
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| Predicted Species Reactivity | Homo sapiens|Human |
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| Product Format | Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose. |
| Conjugation | Ovalbumin |
| Application | ICC, IF |
| Additional Information | PubChem: Ab1-42 |
| :: | Chemical Formula: C5H9N3 |
| Reconstitution and Storage | 2°C to 8°C|-80°C |
| Purity | > 90% |
| Formulation | PBS, pH7.4. |
| Tag | N-terminal His Tag |
| Gene Symbol | APP |
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| Gene Full Name | amyloid beta precursor protein |
| Alias Symbols | AAA;ABETA;ABPP;AD1;alpha-sAPP;alzheimer disease amyloid protein;amyloid beta (A4) precursor protein;amyloid beta A4 protein;amyloid precursor protein;amyloid-beta precursor protein;APPI;beta-amyloid peptide;beta-amyloid peptide(1-40);beta-amyloid peptide(1-42);beta-amyloid precursor protein;cerebral vascular amyloid peptide;CTFgamma;CVAP;peptidase nexin-II;PN2;PN-II;preA4;protease nexin-II;testicular tissue protein Li 2. |
| NCBI Gene Id | 351 |
| Protein Name | Amyloid-beta A4 protein |
| Description of Target | Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1. |
| Uniprot ID | P05067 |
| Molecular Weight | 111.2 Da |