Anti-CD147/BSG antibody (Clone: HIM6) {AF647}

Clonality:	Monoclonal
Clone ID:	HIM6
Conjugation:	AF647
Isotype:	IgG1k
Formulation:	PBS with 0.05% Proclin300, 1% BSA
Storage Instruction:	Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.

Gene Symbol:	BSG
Gene ID:	682
Uniprot ID:	BASI_HUMAN

Tissue Specificity	Isoform 1: Retina-specific. Expressed in retinal cone photoreceptors (at protein level). Isoform 2: Expressed in erythrocytes (at protein level). Highly expressed in melanoma cell lines (at protein level). Highly expressed in the heart, kidney, skeletal muscle and testis. Isoform 3: Highly expressed in the bone marrow, fetal liver, lung, testis and thymus. Isoform 4: Highly expressed in the bone marrow, fetal liver, lung, testis and thymus.
Post Translational Modifications	Isoform 2: N-glycosylated. Isoform 3: N-glycosylated. Isoform 4: N-glycosylated.
Function	Isoform 1: Essential for normal retinal maturation and development. Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors. In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors. May act as a potent stimulator of IL6 secretion in multiple cell lines that include monocytes. Isoform 1: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7 and Dd2. Isoform 2: Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells. Plays an important role in targeting monocarboxylate transporters SLC16A1/GLUT1, SLC16A11 and SLC16A12 to the plasma membrane. Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling. Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA (isoform VEGF-165 and VEGF-121) and KDR/VEGFR2 in endothelial cells. Plays a key role in regulating tumor growth, invasion, metastasis and neoangiogenesis by stimulating the production and release of extracellular matrix metalloproteinases and KDR/VEGFR2 by both tumor cells and stromal cells (fibroblasts and endothelial cells). Isoform 2: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7, Dd2, 7G8 and HB3. Binding of P.falciparum RH5 results in BSG dimerization which triggers an increase in intracellular Ca(2+) in the erythrocyte. This essential step leads to a rearrangement of the erythrocyte cytoskeleton required for the merozoite invasion. Isoform 2: (Microbial infection) Can facilitate human SARS coronavirus (SARS-CoV-1) infection via its interaction with virus-associated PPIA/CYPA. Isoform 2: (Microbial infection) Can facilitate HIV-1 infection via its interaction with virus-associated PPIA/CYPA. Isoform 2: (Microbial infection) First described as a receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is not required for SARS-CoV-2 infection. Isoform 2: (Microbial infection) Acts as a receptor for measles virus. Isoform 2: (Microbial infection) Promotes entry of pentamer-expressing human cytomegalovirus (HCMV) into epithelial and endothelial cells.
Protein Name	Basigin 5f7 Collagenase Stimulatory Factor Extracellular Matrix Metalloproteinase Inducer Emmprin Hepatoma-Associated Antigen Hab18g Leukocyte Activation Antigen M6 Ok Blood Group Antigen Tumor Cell-Derived Collagenase Stimulatory Factor Tcsf Cd Antigen Cd147
Database Links	Reactome: R-HSA-1474228 Reactome: R-HSA-210991 Reactome: R-HSA-216083 Reactome: R-HSA-433692 Reactome: R-HSA-5619070 Reactome: R-HSA-70268 Reactome: R-HSA-9749641
Cellular Localisation	Melanosome Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv Isoform 1: Cell Membrane Single-Pass Type I Membrane Protein Photoreceptor Inner Segment Cell Projection Cilium Photoreceptor Outer Segment Isoform 2: Cell Membrane Endosome Endoplasmic Reticulum Membrane Basolateral Cell Membrane Isoform 3: Cell Membrane Isoform 4: Cell Membrane
Alternative Antibody Names	Anti-Basigin antibody Anti-5f7 antibody Anti-Collagenase Stimulatory Factor antibody Anti-Extracellular Matrix Metalloproteinase Inducer antibody Anti-Emmprin antibody Anti-Hepatoma-Associated Antigen antibody Anti-Hab18g antibody Anti-Leukocyte Activation Antigen M6 antibody Anti-Ok Blood Group Antigen antibody Anti-Tumor Cell-Derived Collagenase Stimulatory Factor antibody Anti-Tcsf antibody Anti-Cd Antigen Cd147 antibody Anti-BSG antibody Anti-UNQ6505 antibody Anti-PRO21383 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance