Anti-CD279 (PD-1) (Human) mAb (Monoclonal Antibody)
| Target | PD-1 |
|---|---|
| Product Type | Antibody |
| Application | FCM, WB |
| Clonality | Monoclonal |
| Conjugate | Unlabeled |
| Isotype | IgG1 |
| Immunogen | Fusion protein of human PD-1-Fc |
| Host Species | Mouse |
| Species Reactivity | Human |
| Formulation | 1.0 mg/mL in PBS/50% glycerol, pH 7.2 |
| Research Area | Cancer, Immunology |
| Description/Background | Human PD-1 (programmed death-1) is a 55 kDa member of the immunoglobulin superfamily that is induced in cells undergoing apoptosis. The PD-1 protein contains an immunoreceptor tyrosine-based inhibitory motif and is expressed predominantly on activated T and B lymphocytes. PD-1 plays a key role in peripheral tolerance and autoimmune disease and is thought to be involved in the maintenance of peripheral self-tolerance by serving as a negative regulator of immune responses. Two novel members of the B7 family have been identified as PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and up-regulation on activated antigen-presenting cells. |
| Storage Temperature | -20°C |
| Protocols | FCM, WB |
| Clone Number | J110 |
| Concentration | 1 mg/mL |
| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |
D132-3
Antibody
100 μg