APC Conjugated Anti-STRO-1 Monoclonal Antibody (Clone:STRO-1)
Figure 1: Surface staining of human peripheral blood with anti-STRO-1 (STRO-1) APC.
Size : 0,1mg
Figure 1: Surface staining of human peripheral blood with anti-STRO-1 (STRO-1) APC.
Amount : | 0.1 mg |
Isotype : | Mouse IgM |
Storage condition : | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. |
Immunogen Information : | Human CD34 positive bone marrow cells |
STRO-1 is a cell surface antigen expressed by stromal elements in human bone marrow, identified by monoclonal antibody STRO-1. Approximately 10% of mononuclear cells, greater than 95% of which are nucleated erythroid precursors, are STRO-1 positive, whereas the CFU-GM (colony-forming unit granulocyte-macrophage), BFU-E (erythroid burst) and CFU-Mix (mixed colonies) committed progenitor cells are negative. CFU-F (fibroblast colony-forming cells) are present exclusively in the STRO-1 positive population. When plated under long-term bone marrow culture conditions, STRO-1 positive cells generate adherent cell layers containing multiple stromal cell types, including adipocytes, smooth muscle cells, osteoblasts, chondrocytes, and fibroblastic elements. In combination with glycophorin A, STRO-1 is a useful marker for identification of mesenchymal stem cells. STRO-1 and CD117 are markers for osteosarcoma cells.
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