CD46 Mouse Monoclonal Antibody [Clone ID: MEM-258]
Cat# SM1819AF
Size : 100ug
Contatta il distributore locale :
| Product Data | |
| Clone Name | MEM-258 |
|---|---|
| Application | FC, IP, WB |
| Application | Flow cytometry: 1 µg/ml. Immunoprecipitation. Western blot (Non-reducing conditions). |
| Reactivity | Bovine, Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | HPB-ALL human T cell line |
| Specificity | This antibody recognizes an epitope on SCR4 (the membrane-proximal SCR) domain of CD46 (Membrane cofactor protein). CD46 is 56-66 kDa dimeric transmembrane protein expressed on T and B lymphocytes, platelets, monocytes, granulocytes, endothelial cells, epithelial cells and fibroblast; it is negative on erythrocytes. |
| Buffer | Azide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 μm filter sterilized State: Azide Free State: Liquid Ig fraction |
| Concentration | lot specific |
| Purification | Protein-A affinity chromatography (> 95% pure by SDS-PAGE) |
| Conjugation | Unconjugated |
| Storage | Store undiluted at 2-8°C. DO NOT FREEZE! |
| Stability | Shelf life: one year from despatch. |
| Gene Name | CD46 molecule |
| Database Link | |
| Background | CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments, regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction. CD46 also serves as a receptor for several human pathogens (both bacteria and viruses), and its ligation alteres T lymphocyte polarization toward antigen-presenting cells or target cells, inhibiting lymphocyte function. CD46 is a protector of placental tissue and is also expressed on the inner acrosomal membrane of spermatozoa. |
| Synonyms | TLX, MIC10 |
| Reference Data | |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Complement and coagulation cascades |
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