Chroman 1 [1273579-40-0]
Cat# HY-15392-5mg
Size : 5mg
Marca : MedChemExpress
Chroman 1 is a highly potent and selective ROCK inhibitor. Chroman 1 is more potent against ROCK2 (IC50=1 pM) than ROCK1 (IC50=52 pM). Chroman 1 also has inhibitory activity against MRCK, with an IC50 of 150 nM.
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Chroman 1 Chemical Structure
CAS No. : 1273579-40-0
This product is a controlled substance and not for sale in your territory.
Based on 21 publication(s) in Google Scholar
Other Forms of Chroman 1:
- Chroman 1 dihydrochloride In-stock
Description |
Chroman 1 is a highly potent and selective ROCK inhibitor. Chroman 1 is more potent against ROCK2 (IC50=1 pM) than ROCK1 (IC50=52 pM). Chroman 1 also has inhibitory activity against MRCK, with an IC50 of 150 nM[1][2]. |
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IC50 & Target[1][2] |
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In Vitro |
Chroman 1 (50 nM, 24 h) inhibits caspase-3/7 activation and reduces apoptosis in human pluripotent stem cells[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis Analysis[1]
Western Blot Analysis[1]
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Masse moléculaire |
436.50 |
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Formule |
C24H28N4O4 |
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CAS No. |
1273579-40-0 |
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Appearance |
Solid |
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Color |
White to pink |
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SMILES |
O=C([C@@H]1COC2=CC=C(OC)C=C2C1)NC3=CC=C(C4=CNN=C4)C=C3OCCN(C)C |
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Livraison | Room temperature in continental US; may vary elsewhere. |
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Stockage |
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Solvant et solubilité |
In Vitro:
DMSO : ≥ 50 mg/mL (114.55 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) *"≥" means soluble, but saturation unknown. Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Pureté et documentation | |||||||||||||||||
Références |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 2.2910 mL | 11.4548 mL | 22.9095 mL | 57.2738 mL |
5 mM | 0.4582 mL | 2.2910 mL | 4.5819 mL | 11.4548 mL | |
10 mM | 0.2291 mL | 1.1455 mL | 2.2910 mL | 5.7274 mL | |
15 mM | 0.1527 mL | 0.7637 mL | 1.5273 mL | 3.8183 mL | |
20 mM | 0.1145 mL | 0.5727 mL | 1.1455 mL | 2.8637 mL | |
25 mM | 0.0916 mL | 0.4582 mL | 0.9164 mL | 2.2910 mL | |
30 mM | 0.0764 mL | 0.3818 mL | 0.7637 mL | 1.9091 mL | |
40 mM | 0.0573 mL | 0.2864 mL | 0.5727 mL | 1.4318 mL | |
50 mM | 0.0458 mL | 0.2291 mL | 0.4582 mL | 1.1455 mL | |
60 mM | 0.0382 mL | 0.1909 mL | 0.3818 mL | 0.9546 mL | |
80 mM | 0.0286 mL | 0.1432 mL | 0.2864 mL | 0.7159 mL | |
100 mM | 0.0229 mL | 0.1145 mL | 0.2291 mL | 0.5727 mL |
Chroman 1 Related Classifications
- Cell Cycle/DNA Damage TGF-beta/Smad Stem Cell/Wnt Cytoskeleton
- ROCK