OUR CUX1/CUL1 probe is designed to detect copy number variations of CUX1 and CUL1. The probe comes labeled in orange and green, but can be customized to meet your needs.
Gene Background: Chromosome 7 aberrations, either monosomy or 7q deletion, are the most frequent cytogenetic abnormalities found in acute myeloid leukemia and myelodysplastic syndromes, occurring in 8% of de novo acute myeloid leukemia (AML), 5-10% of myelodysplastic syndrome (MDS), and roughly 50% of therapy-related myeloid neoplasms.1 Loss of heterozygosity (LOH) studies have identified a 2 to 3 Mb segment in 7q22 as the common proximal deletion area, and the 7q33-34 zone as the accompanying distal deletion area, although deletions also occur in 7q32-33 and 7q35-36.1 CUX1 is found at the commonly deleted region (CDR) in 7q22, and acts as a tumor suppressor through the regulation of proliferative genes. 2 CUL1 is found another CDR at 7q35-36, and encodes a ubiquitination protein that aid in cell cycle progression, signal transduction, and transcription.3
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
Gene Summary
The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Feb 2011]
Gene Details
Gene Symbol: CUX1
Gene Name: Cut Like Homeobox 1
Chromosome: CHR7: 101459183-101927250
Locus: 7q22.1