Cx3cl1 Mouse shRNA Plasmid (Locus ID 20312)
Cat# TR514650
Size : 1kit
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Cx3cl1 Mouse shRNA Plasmid (Locus ID 20312)
SKU
TR514650
Cx3cl1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
In Stock*
| Product Data | |
| Locus ID | 20312 |
|---|---|
| Synonyms | AB030188; ABCD-3; AI848747; CX3C; Cxc3; D8Bwg0439e; Scyd1 |
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Format | Retroviral plasmids |
| Components | Cx3cl1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 20312). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | BC006650, BC054838, NM_009142, NM_009142.1, NM_009142.2, NM_009142.3, BC013336, BC057891 |
| UniProt ID | O35188 |
| Summary | Acts as a ligand for both CX3CR1 and integrins. Binds to CX3CR1 and to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1 (By similarity). The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium (PubMed:9177350, PubMed:10382755).[UniProtKB/Swiss-Prot Function] |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact tech@clinisciences.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.