Deferoxamine (mesylate) [138-14-7]
Cat# HY-B0988-100mg
Size : 100mg
Marca : MedChemExpress
Deferoxamine mesylate (Deferoxamine B mesylate) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine mesylate upregulates HIF-1α levels with good antioxidant activity. Deferoxamine mesylate also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine mesylate can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19.
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Deferoxamine mesylate Chemical Structure
CAS No. : 138-14-7
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Based on 232 publication(s) in Google Scholar
Other Forms of Deferoxamine mesylate:
- Deferoxamine Obtenir un devis
- Deferoxamine mesylate (Standard) Obtenir un devis
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Deferoxamine mesylate purchased from MedChemExpress. Usage Cited in: Sci Adv. 2022 Mar 4;8(9):eabm1896. [Abstract]
- PAI1 mRNA expression in iHUVEC treated with increasing doses of either CoCl2, Deferoxamine (DFO), 1, 4-DPCA or DMOG.
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Deferoxamine mesylate purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2022 Aug 15;436:129043. [Abstract]
- The specific inhibitor of ferroptosis Fer-1 (100 μM) and Lip-1 (5 μM), and the iron chelator Deferoxamine (DFOM;100 μM) restored the cellular activity of RAW264.7 macrophages after treatment for 24 h.
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Deferoxamine mesylate purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2022 Aug 15;436:129043. [Abstract]
- Deferoxamine (DFOM; 100 μM; 24 h) attenuated the abnormal increase of ROS and LPO in macrophages elicited by CdTe QDs.
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Deferoxamine mesylate purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2021 Nov 19;13:23-36. [Abstract]
- H1299 cells are treated with Curcumenol with or without Deferoxamine (DFO; 20 μM) for 24 h, and the cell viability is analyzed.
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Deferoxamine mesylate purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2021 Nov 19;13:23-36. [Abstract]
- The expression of ferroptosis-related proteins in lung cancer cells is detected after Curcumenol treatment with or without Deferoxamine (DFO; 20 μM) by western blotting.
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Deferoxamine mesylate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2021 Mar 8;8(10):2004680. [Abstract]
- Deferoxamine (DFO; 0.5 μM; for 48 h) could rescue iron overload‐induced cell death in both iHep‐Orgs and iHep.
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Deferoxamine mesylate purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2021 Jun;11(6):1513-1525. [Abstract]
- Deferoxamine (DFO; 10 μM; 72 h) can markedly reverse the cell growth prevented by a2 in MGC-803 and MKN-45 cells.
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Deferoxamine mesylate purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2021 Jun 23;40(1):206. [Abstract]
- Propidium iodide staining confirmed that DFO inhibited metformin-induced cell death in T47D cells Deferoxamine (20 μM; 48 h).
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Deferoxamine mesylate purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2020 May 8;5(1):51. [Abstract]
- Representative results of wound healing after the treatment with the combination of ferroptosis inhibitor DFO and erianin. The expression of EMT markers E-Cadherin and N-Cadherin are examined by western blotting.
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Deferoxamine mesylate purchased from MedChemExpress. Usage Cited in: Theranostics. 2020 Apr 6;10(11):5107-5119. [Abstract]
- The cell death induced by the treatment with β-elemene and cetuximab in KRAS mutant CRC cells is almost completely blocked by treatment with ferroptosis rescue agents Deferoxamine (DFO; 20 nM; 24 h), Liproxstatin-1 (Lip-1) or Ferrostatin-1 (Fer-1).
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Deferoxamine mesylate purchased from MedChemExpress. Usage Cited in: J Bone Miner Res. 2020 Jun;35(6):1163-1173. [Abstract]
- The expression of iron metabolism related protein is assessed by western blot. Protein levels of FPN1 and hepcidin1 in the liver. BL: The baseline group, mice are raised with under the GMF for 4 weeks. HLU: Mice hindlimb are unloaded and raised for 4 weeks. GMF: Mice are kept in a wooden experimental box with the normal GMF for 8 weeks. HyMF: Mice are raised in a GMF-shielded room for 8 weeks. HLU+GMF: HLU mice are reloaded and raised in a wooden box for 4 weeks. HLU+HyMF: HLU mice are reloaded
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Deferoxamine mesylate purchased from MedChemExpress. Usage Cited in: J Bone Miner Res. 2020 Jun;35(6):1163-1173. [Abstract]
- The expression of iron metabolism related protein was assessed by western blot. Protein levels of TfR1, FTH1 and FPN1 in the tibia. BL: The baseline group, mice are raised with under the GMF for 4 weeks. HLU: Mice hindlimb are unloaded and raised for 4 weeks. GMF: Mice are kept in a wooden experimental box with the normal GMF for 8 weeks. HyMF: Mice are raised in a GMF-shielded room for 8 weeks. HLU+GMF: HLU mice are reloaded and raised in a wooden box for 4 weeks. HLU+HyMF: HLU mice are reloade
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Deferoxamine mesylate purchased from MedChemExpress. Usage Cited in: Cell Res. 2018 Dec;28(12):1171-1185. [Abstract]
- The FTL- or FTH1-knockdown A375 cells are pretreated with or without DFO (50 μM) for 2 h before CCCP stimulation. The pyroptotic morphology and LDH release are indicated.
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Deferoxamine mesylate purchased from MedChemExpress. Usage Cited in: ACS Appl Mater Interfaces. 2018 Feb 21;10(7):6180-6189. [Abstract]
- Quantitative analyses confirm the steady increase of blood vessels over the course of implantation of DFO-loading Gp gel.