DR5 antibody [DR5-01-1]
Cat# GTX80178-100ug
Size : 100ug
Marca : GeneTex
Contatta il distributore locale :
Telefono : +1 850 650 7790
Host | Mouse |
|---|---|
Clonality | Monoclonal |
Clone Name | DR5-01-1 |
Isotype | IgG1 |
Application | FACS |
Reactivity | Human |
| Package | 100 μg |
Datasheet File View product citations for antibody GTX80178 on CiteAb
APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application | Recommended Dilution |
|---|---|
| FACS | Assay dependent |
Not tested in other applications.
Calculated MW
48 kDa. ( Note )
Product Note
This antibody recognizes an extracellular domain of TRAIL-R2 (DR5).
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
15mM Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Recombinant fusion protein of human IgG heavy chain and extracellular domain of DR5.
Purification
Protein A purified
Conjugation
Unconjugated
RRID
AB_11178449
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
CD262 , DR5 , KILLER , KILLER/DR5 , TNF receptor superfamily member 10b , TNFRSF10B , TRAILR2 , TRICK2 , TRICK2A , TRICK2B , TRICKB , ZTNFR9 , TRAIL-R2
Cellular Localization
Membrane
Background
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]
Database
Application Reference
?rtykov ?? et al. Cancers (Basel) 2020; 12 (5) Chemotherapeutic Agents Sensitize Resistant Cancer Cells to the DR5-Specific Variant DR5-B more Efficiently than to TRAIL by Modulating the Surface Expression of Death and Decoy Receptors.
Application : FACS
Yagolovich AV et al. Transl Oncol 2020; 13 (4) : 100762 Genetically Modified DR5-Specific TRAIL Variant DR5-B Revealed Dual Antitumor and Protumoral Effect in Colon Cancer Xenografts and an Improved Pharmacokinetic Profile.
REVIEW
Application Reference
?rtykov ?? et al. Cancers (Basel) 2020; 12 (5) Chemotherapeutic Agents Sensitize Resistant Cancer Cells to the DR5-Specific Variant DR5-B more Efficiently than to TRAIL by Modulating the Surface Expression of Death and Decoy Receptors.
Application : FACS
Yagolovich AV et al. Transl Oncol 2020; 13 (4):100762 Genetically Modified DR5-Specific TRAIL Variant DR5-B Revealed Dual Antitumor and Protumoral Effect in Colon Cancer Xenografts and an Improved Pharmacokinetic Profile.
| SDS | |
|---|---|
| PBS.pdf | |
| Sodium Azide.pdf | |
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