Floxuridine [50-91-9]
Cat# HY-B0097-500mg
Size : 500mg
Marca : MedChemExpress
Floxuridine (5-Fluorouracil 2'-deoxyriboside) is a pyrimidine analog and known as an oncology antimetabolite. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage by activating the ATM and ATR checkpoint signaling pathways in vitro. Floxuridine is a extreamly potent inhibitor for S. aureus infection and induces cell apoptosis. Floxuridine has antiviral effects against HSV and CMV.
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Floxuridine Chemical Structure
CAS No. : 50-91-9
This product is a controlled substance and not for sale in your territory.
Based on 7 publication(s) in Google Scholar
Other Forms of Floxuridine:
- Floxuridine (Standard) Obtenir un devis
Voir tous les produits spécifiques à Isoform HSV:
Description |
Floxuridine (5-Fluorouracil 2'-deoxyriboside) is a pyrimidine analog and known as an oncology antimetabolite. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage by activating the ATM and ATR checkpoint signaling pathways in vitro. Floxuridine is a extreamly potent inhibitor for S. aureus infection and induces cell apoptosis[1][2]. Floxuridine has antiviral effects against HSV and CMV[3]. |
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IC50 & Target[1][2][3] |
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In Vitro |
Floxuridine (0-25 μM; 4-24 hours) is affectd by inhibitors of PARP and its sensitivity of ovarian cancer cells is enhanced. Co-exposed to FdUrd and the PARP inhibitor markedly increases killing cell numbers when its compare to treatment alone in ovarian cancer cells[1]. Floxuridine (300 μM; 4-24 hours) increases p-Chk1 and p-Chk2 in ovarian cancer cell lines. It may induce DNA damage and activate the ATM and ATR checkpoint signaling pathways[1].Floxuridine (0-2.5 μM; 24 hours) causes a G1/S-phase arrest and following removal of the FdUrd, the G1/S-phase-arrested cells moved synchronously through S phase and into G2/M[1].Floxuridine is also a very potent inhibitor of staphylococcal growth (MIC, 0.025–0.00313 μM)[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[1]
Western Blot Analysis[1]
Cell Cycle Analysis[1]
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In Vivo |
Floxuridine (intraperitoneal injection; 0.5-1.25 mg/kg; once per day for 7 days or single dose) is sufficient to show statistically significant protection against S. aureus infection at 0.5 mg/kg for 7 days. In addition, 1.25 mg/kg single administration of the compound shows statistically significant protection against S. aureus infection[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Essai clinique |
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Masse moléculaire |
246.19 |
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Formule |
C9H11FN2O5 |
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CAS No. |
50-91-9 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
OC[C@@H]1[C@@H](O)C[C@H](N2C(NC(C(F)=C2)=O)=O)O1 |
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Livraison | Room temperature in continental US; may vary elsewhere. |
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Stockage |
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Solvant et solubilité |
In Vitro:
DMSO : 125 mg/mL (507.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) H2O : ≥ 50 mg/mL (203.10 mM) *"≥" means soluble, but saturation unknown. Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
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Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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Pureté et documentation |
Purity: 99.95% COA (252 KB) HNMR (260 KB) LCMS (267 KB) Instruction de manipulation (2659 KB) |
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Références |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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H2O / DMSO | 1 mM | 4.0619 mL | 20.3095 mL | 40.6190 mL | 101.5476 mL |
5 mM | 0.8124 mL | 4.0619 mL | 8.1238 mL | 20.3095 mL | |
10 mM | 0.4062 mL | 2.0310 mL | 4.0619 mL | 10.1548 mL | |
15 mM | 0.2708 mL | 1.3540 mL | 2.7079 mL | 6.7698 mL | |
20 mM | 0.2031 mL | 1.0155 mL | 2.0310 mL | 5.0774 mL | |
25 mM | 0.1625 mL | 0.8124 mL | 1.6248 mL | 4.0619 mL | |
30 mM | 0.1354 mL | 0.6770 mL | 1.3540 mL | 3.3849 mL | |
40 mM | 0.1015 mL | 0.5077 mL | 1.0155 mL | 2.5387 mL | |
50 mM | 0.0812 mL | 0.4062 mL | 0.8124 mL | 2.0310 mL | |
60 mM | 0.0677 mL | 0.3385 mL | 0.6770 mL | 1.6925 mL | |
80 mM | 0.0508 mL | 0.2539 mL | 0.5077 mL | 1.2693 mL | |
100 mM | 0.0406 mL | 0.2031 mL | 0.4062 mL | 1.0155 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Floxuridine Related Classifications
- Cell Cycle/DNA Damage Anti-infection Apoptosis
- Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Bacterial CMV HSV Apoptosis