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> GRPR Antibody (Extracellular Domain)

GRPR Antibody (Extracellular Domain)

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Cat# ALS10178

Size : 50ug

Marca : Abcepta

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  • IHC - GRPR Antibody (Extracellular Domain) ALS10178
    Anti-GRPR antibody ALS10178 IHC of human pancreas, islet of Langerhans.
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P30550
Reactivity Human, Rabbit, Monkey, Pig, Horse, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 43kDa
Dilution IHC-P (4 µg/ml)
Additional Information
Gene ID 2925
Other Names Gastrin-releasing peptide receptor, GRP-R, GRP-preferring bombesin receptor, GRPR
Target/Specificity Human GRPR. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsGRPR Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GRPR
Function Receptor for gastrin-releasing peptide (GRP) (PubMed:1655761). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (By similarity). In another study, shown to contribute to disinhibition of glutamatergic cells in the auditory cortex via signaling on vasoactive intestinal peptide- expressing cells which leads to enhanced auditory fear memories (By similarity). Contributes to the induction of sighing through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Highly expressed in pancreas (PubMed:11245983). Also expressed in stomach, adrenal cortex and brain (PubMed:11245983) In brain, expressed in cells throughout the cortex (PubMed:34610277)
Volume 50 µl