Biological Activity

Hemin is an iron-containing porphyrin. Hemin strongly increased both expression and activity of HMOX after 4 and 12 h, respectively. Hemin treatment decreases cell proliferation to 62±5 %, 51±3 %, and 38±8 % in PA-TU-8902, BxPC-3 and MiaPaCa-2 cancer cells, respectively, with p<0.0001 for all comparisons.

In vivo, following the i.p. administration of Hemin (100 μmol/kg), the HO-1 level in the renal cortex begins to increase gradually. The HO-1 level reaches its peak 24 h after Hemin preconditioning. HO-1 is expressed mainly in the renal tubules.

Chemical Information

Molecular Weight	651.94
Formula	C34H32ClFeN4O4
CAS Number	16009-13-5
Solubility (25°C)	1M NaOH: 6 mg/mL (ultrasonic and adjust pH to 12 with NaOH) DMSO ≥ 6 mg/mL (Need ultrasonic and warming)
Storage	4°C, protect from light, sealed

References

[1] Natalie E Palmaers, et al. Distinct Mechanisms Account for In Vitro Activation and Sensitization of TRPV1 by the Porphyrin Hemin

[2] Muhan Zhang, et al. Effect of myoglobin, hemin, and ferric iron on quality of chicken breast meat

[3] Aliye Uc, et al. Hemin induces active chloride secretion in Caco-2 cells

[4] A U Orjih, et al. Hemin lyses malaria parasites

[5] R L Aft, et al. Hemin-mediated DNA strand scission