HSC70/HSP70 (PE)

Cat# 590270-50ug

Size : 50ug

Marca : US Biological

Richiedere ulteriori informazioni

Contatta il distributore locale :


Telefono : +1 850 650 7790


590270 HSC70/HSP70 (PE)

Clone Type
Polyclonal
Host
mouse
Source
human
Swiss Prot
P0DMV8 (HSP70/HSP72), P11142 (HSC70/HSP73)
Isotype
IgG1
Grade
Affinity Purified
Applications
FC
Crossreactivity
Bo Ca Ch Gp Hm Hu Mk Mo Po Rb Rt Sh Xe
Shipping Temp
Blue Ice
Storage Temp
4°C Do Not Freeze

The Hsp70 family of heat shock protiens contains multiple homologs ranging in size from 66-78kD, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.||Applications: |Suitable for use in Flow Cytometry. Other applications not tested.||Recommended Dilutions:|Flow Cytometry: 10ug/ml|Optimal dilutions to be determined by the researcher.||Storage and Stability|Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Applications
Product Type: Mab|Isotype: IgG1|Clone No: N27F3-4|Host: mouse|Source: human|Concentration: As Reported |Form: Supplied as a liquid in PBS, 0.09% sodium azide, 50% glycerol. Labeled with R-Phycoerythrin (PE). |Purity: Purified by Protein G affinity chromatography from ascites.|Immunogen: Purified Hsc70 (Hsp73) and Hsp70 (Hsp72) isolated from human HeLa cells.|Specificity: Recognizes human HSC70. Species Crossreactivity: human, mouse, rat|beluga, bovine, chicken, canine, fish, guinea pig, hamster, monkey, porcine, plant, rabbit, sheep and xenopus||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Immunogen
Purified Hsc70 (Hsp73) and Hsp70 (Hsp72) isolated from human HeLa cells.
Form
Supplied as a liquid in PBS, 0.09% sodium azide, 50% glycerol. Labeled with R-Phycoerythrin (PE).
Purity
Purified by Protein G affinity chromatography from ascites.
Specificity
Recognizes human HSC70. Species Crossreactivity: human, mouse, rat|beluga, bovine, chicken, canine, fish, guinea pig, hamster, monkey, porcine, plant, rabbit, sheep and xenopus