Purified human LDL (d=1.019 - 1.063 g/mL) is extensively oxidized with copper (II) sulfate to provide a High Oxidized LDL. It is dialyzed and ultrafiltered through a membrane and packaged aseptically under nitrogen. The product is provided in a solution with 154 mM NaCl, 5.6 mM Na2HPO4, 1.1 mM KH2PO4, and 0.34 mM EDTA, at pH 7.4.

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Research Using This Product

• The SCFFBXO3 ubiquitin E3 ligase regulates inflammation in atherosclerosis

• A positive feedback loop between IL-1β, LPS and NEU1 may promote atherosclerosis by enhancing a pro-inflammatory state in monocytes and macrophages