Human Metabotropic Glutamate Receptor 8 (GRM8) activation kit by CRISPRa
Cat# GA101973
Size : 1kit
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Human Metabotropic Glutamate Receptor 8 (GRM8) activation kit by CRISPRa
SKU
GA101973
GRM8 CRISPRa kit - CRISPR gene activation of human glutamate metabotropic receptor 8
2 Weeks*
| Product Data | |
| Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
|---|---|
| Target Symbol | GRM8 |
| Locus ID | 2918 |
| Components | GA101973G1, Metabotropic Glutamate Receptor 8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA101973G2, Metabotropic Glutamate Receptor 8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA101973G3, Metabotropic Glutamate Receptor 8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
| Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
| Reference Data | |
| RefSeq | NM_000845, NM_001127323, NM_001127326, NR_028041 |
| UniProt ID | O00222 |
| Synonyms | GLUR8; GPRC1H; mGlu8; MGLUR8 |
| Summary | L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
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| SDS |
| SKU | Description | Size | ||
|---|---|---|---|---|
| KN410813 | GRM8 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. | 1 kit | | |
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.