Human STX1A (Syntaxin 1A, Brain) Sandwich ELISA Kit

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	STX1A
Gene ID:	6804
Uniprot ID:	STX1A_HUMAN
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Isoform 1: Highly expressed in embryonic spinal cord and ganglia and in adult cerebellum and cerebral cortex. Isoform 2: Expressed in heart, liver, fat, skeletal muscle, kidney and brain.
Post Translational Modifications	Phosphorylated by CK2. Phosphorylation at Ser-188 by DAPK1 significantly decreases its interaction with STXBP1. Sumoylated, sumoylation is required for regulation of synaptic vesicle endocytosis.
Function	Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion. Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm. Also plays an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1).
Protein Name	Syntaxin-1a Neuron-Specific Antigen Hpc-1
Database Links	Reactome: R-HSA-181429 Reactome: R-HSA-181430 Reactome: R-HSA-210500 Reactome: R-HSA-212676 Reactome: R-HSA-264642 Reactome: R-HSA-264876 Reactome: R-HSA-422356 Reactome: R-HSA-449836 Reactome: R-HSA-5250971 Reactome: R-HSA-5682910 Reactome: R-HSA-6794361 Reactome: R-HSA-888590 Reactome: R-HSA-9609523 Reactome: R-HSA-9662360
Cellular Localisation	Cytoplasmic Vesicle Secretory Vesicle Synaptic Vesicle Membrane Single-Pass Type Iv Membrane Protein Synapse Synaptosome Cell Membrane Colocalizes With Kcnb1 At The Cell Membrane Isoform 2: Secreted
Alternative ELISA Names	Syntaxin-1a ELISA kit Neuron-Specific Antigen Hpc-1 ELISA kit STX1A ELISA kit STX1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance