I-191 [1690172-25-8]
Cat# HY-117793-5mg
Size : 5mg
Marca : MedChemExpress
Contatta il distributore locale :
Telefono : +1 850 650 7790
I-191 is a potent, selective protease-activated receptor 2 (PAR2) antagonist.
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I-191 Chemical Structure
CAS No. : 1690172-25-8
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
| Description |
I-191 is a potent, selective protease-activated receptor 2 (PAR2) antagonist[1]. |
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| IC50 & Target |
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| In Vitro |
I-191 inhibits cytokine production as well as cytokine-related caspase cleavages via ERK1/2 signaling in HT29 colon cancer cells[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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| Masse moléculaire |
423.48 |
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| Formule |
C23H26FN5O2 |
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| CAS No. |
1690172-25-8 |
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| Appearance |
Solid |
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| Color |
White to gray |
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| SMILES |
O=C1NCCN(C(C2=CN3N=C(C4=CC=C(F)C=C4)C=C(C(C)(C)C)C3=N2)=O)C1(C)C |
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| Livraison | Room temperature in continental US; may vary elsewhere. |
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| Stockage |
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| Solvant et solubilité |
In Vitro:
DMSO : 8.33 mg/mL (19.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) H2O : < 0.1 mg/mL (insoluble) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
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Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
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| Pureté et documentation |
Purity: 99.38% |
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| Références |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.3614 mL | 11.8069 mL | 23.6139 mL | 59.0347 mL |
| 5 mM | 0.4723 mL | 2.3614 mL | 4.7228 mL | 11.8069 mL | |
| 10 mM | 0.2361 mL | 1.1807 mL | 2.3614 mL | 5.9035 mL | |
| 15 mM | 0.1574 mL | 0.7871 mL | 1.5743 mL | 3.9356 mL |