Interleukin-2 (IL-2) (Human, Recombinant)

Product Description

Human Interleukin-2 (IL-2)
Catalog number: B2010268
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: n/a
Supplied as: Reconstitute before use
Appearance: Solid
Applications: highly pure recombinant human Interleukin 2 (IL-2, expressed in CHO cells). IL-2 is an important hematopoietic growth factor as well as an immune response modulator.
Storage: -20C
Keywords: rHuIL-2; IL2; T-cell Growth Factor; TCGF; Aldesleukin
Grade: Biotechnology grade. All components are highly pure (minimum 99%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered on a 0.22 um.

References:
1: Marabondo S, Kaufman HL. High-dose interleukin-2 (IL-2) for the treatment of
melanoma: safety considerations and future directions. Expert Opin Drug Saf.
2017 Dec;16(12):1347-1357.

2: Mitra S, Leonard WJ. Biology of IL-2 and its therapeutic modulation:
Mechanisms and strategies. J Leukoc Biol. 2018 Apr;103(4):643-655.

3: von Spee-Mayer C, Siegert E, Abdirama D, Rose A, Klaus A, Alexander T,
Enghard P, Sawitzki B, Hiepe F, Radbruch A, Burmester GR, Riemekasten G, Humrich
JY. Low-dose interleukin-2 selectively corrects regulatory T cell defects in
patients with systemic lupus erythematosus. Ann Rheum Dis. 2016
Jul;75(7):1407-15.

4: Shao M, He J, Zhang R, Zhang X, Yang Y, Li C, Liu X, Sun X, Li Z.
Interleukin-2 Deficiency Associated with Renal Impairment in Systemic Lupus
Erythematosus. J Interferon Cytokine Res. 2019 Feb;39(2):117-124.

5: Carmenate T, Pacios A, Enamorado M, Moreno E, Garcia-Martínez K, Fuente D,
León K. Human IL-2 mutein with higher antitumor efficacy than wild type IL-2. J
Immunol. 2013 Jun 15;190(12):6230-8.

6: Grabstein K, Dower S, Gillis S, Urdal D, Larsen A. Expression of interleukin
2, interferon-gamma, and the IL 2 receptor by human peripheral blood
lymphocytes. J Immunol. 1986 Jun 15;136(12):4503-8.

7: Asahina Y, Komiya S, Ohagi A, Fujimoto R, Tamagaki H, Nakagawa K, Sato T,
Akira S, Takao T, Ishii A, Nakahara Y, Hojo H. Chemical Synthesis of
O-Glycosylated Human Interleukin-2 by the Reverse Polarity Protection Strategy.
Angew Chem Int Ed Engl. 2015 Jul 6;54(28):8226-30.

Products Related to Human Interleukin-2 (IL-2): COVID-19