IRAK1 Antibody
Cat# OASG03951
Size : 100ul
Marca : Aviva Systems Biology
Contatta il distributore locale :
Telefono : +1 850 650 7790
| Datasheets/Manuals | Printable datasheet for anti-IRAK1 (OASG03951) antibody |
|---|
| Predicted Species Reactivity | Human |
|---|---|
| Product Format | Liquid PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Host | Rabbit |
| Application | WB, IHC |
| Additional Information | Cellular Localization: Cytoplasm Nucleus Lipid droplet. Translocates to the nucleus when sumoylated. RSAD2/viperin recruits it to the lipid droplet. Tissue Specificity: Isoform 1 and isoform 2 are ubiquitously expressed in all tissues examined, with isoform 1 being more strongly expressed than isoform 2. |
| Reconstitution and Storage | Store at -20°C. Avoid repeated freeze/thaw cycles. |
| Immunogen | Synthesized peptide derived from human IRAK-1 around the non-phosphorylation site of T209. Location: 150-230aa. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Specificity | IRAK-1 Polyclonal Antibody detects endogenous levels of IRAK-1 protein. |
| Application Info | WB: 1:500~2000 IHC: 1:100~300 ELISA: 1:20000 |
| Gene Symbol | IRAK1 |
|---|---|
| Gene Full Name | interleukin-1 receptor-associated kinase 1 |
| Alias Symbols | IRAK, pelle |
| NCBI Gene Id | 3654; |
| Description of Target | Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3. |
| Uniprot ID | P51617 |
| Molecular Weight | 77 kDa |
-
What is the species homology for "IRAK1 Antibody (OASG03951)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".
-
How long will it take to receive "IRAK1 Antibody (OASG03951)"?
This item is available "Domestic: within 2-3 weeks delivery | International: 2-3 weeks".
-
What buffer format is "IRAK1 Antibody (OASG03951)" provided in?
This item is provided in "Liquid PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "IRAK1 Antibody (OASG03951)"?
This target may also be called "IRAK, pelle" in publications.
-
What is the shipping cost for "IRAK1 Antibody (OASG03951)"?
The shipping cost for this item is within the US. Please contact us for specific shipping for international orders.
-
What is the guarantee for "IRAK1 Antibody (OASG03951)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
-
Can I get bulk pricing for "IRAK1 Antibody (OASG03951)"?
You can get bulk pricing for this item by going here.
-
What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "77 kDa".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "IRAK1 Antibody (OASG03951)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
-
What are positive controls for "IRAK1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
-
What are negative controls for "IRAK1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
-
What other proteins interact with "IRAK1"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
-
What biological processes are associated with "IRAK1"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
-
What cellular components are associated with "IRAK1"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
-
What protein functions are associated with "IRAK1"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.