Istaroxime (hydrochloride) [374559-48-5]
Cat# HY-15718A-10mg
Size : 10mg
Marca : MedChemExpress
Istaroxime hydrochloride is a Na+/K+-ATPase inhibitor (IC50=0.11 μM) and a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA 2) activator.
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Istaroxime hydrochloride Chemical Structure
CAS No. : 374559-48-5
This product is a controlled substance and not for sale in your territory.
Based on 5 publication(s) in Google Scholar
Other Forms of Istaroxime hydrochloride:
- Istaroxime Obtenir un devis
Voir tous les produits spécifiques à Isoform Calcium Channel:
Description |
Istaroxime hydrochloride is a Na+/K+-ATPase inhibitor (IC50=0.11 μM) and a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA 2) activator. |
IC50 & Target |
IC50: 0.11 μM (Na+,K+-ATPase)[1] |
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In Vitro |
Istaroxime hydrochloride acting as a positive inotropic compound through the inhibition of the Na+,K+-ATPase[2]. Istaroxime (PST2744) inhibits the Na+/K+-ATPase activity from dog kidney with an IC50 value of 0.43 ± 0.15 μM. Inhibition of Na+/K+-ATPase activity in preparations from guinea pig kidney yielded potencies of 8.5 μM for PST2744[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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In Vivo |
Istaroxime (PST2744) induces a progressive increase in +dP/dtmax throughout the infusion that reaches 80% (ED80) at the cumulative dose of 1.89±0.37 mg/kg and a peak of 140±3.5% at the dose (EDmax) of 4.88±0.6 mg/kg[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Essai clinique |
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Masse moléculaire |
396.95 |
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Formule |
C21H33ClN2O3 |
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CAS No. |
374559-48-5 |
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Appearance |
Solid |
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Color |
White to light brown |
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SMILES |
O=C1CC[C@@]2(18)[C@]3(18)CC([C@@]4(18)C/C(CC[C@]4(C)[C@@]3(18)CC[C@@]21C)=N/OCCN)=O.18Cl |
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Livraison | Room temperature in continental US; may vary elsewhere. |
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Stockage |
4°C, sealed storage, away from moisture *In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture) |
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Solvant et solubilité |
In Vitro:
DMSO : ≥ 45 mg/mL (113.36 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) H2O : 25 mg/mL (62.98 mM; Need ultrasonic) *"≥" means soluble, but saturation unknown. Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
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Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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Pureté et documentation | |||||||||||||
Références |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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H2O / DMSO | 1 mM | 2.5192 mL | 12.5960 mL | 25.1920 mL | 62.9800 mL |
5 mM | 0.5038 mL | 2.5192 mL | 5.0384 mL | 12.5960 mL | |
10 mM | 0.2519 mL | 1.2596 mL | 2.5192 mL | 6.2980 mL | |
15 mM | 0.1679 mL | 0.8397 mL | 1.6795 mL | 4.1987 mL | |
20 mM | 0.1260 mL | 0.6298 mL | 1.2596 mL | 3.1490 mL | |
25 mM | 0.1008 mL | 0.5038 mL | 1.0077 mL | 2.5192 mL | |
30 mM | 0.0840 mL | 0.4199 mL | 0.8397 mL | 2.0993 mL | |
40 mM | 0.0630 mL | 0.3149 mL | 0.6298 mL | 1.5745 mL | |
50 mM | 0.0504 mL | 0.2519 mL | 0.5038 mL | 1.2596 mL | |
60 mM | 0.0420 mL | 0.2099 mL | 0.4199 mL | 1.0497 mL | |
DMSO | 80 mM | 0.0315 mL | 0.1575 mL | 0.3149 mL | 0.7873 mL |
100 mM | 0.0252 mL | 0.1260 mL | 0.2519 mL | 0.6298 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Istaroxime hydrochloride Related Classifications
- Membrane Transporter/Ion Channel Neuronal Signaling
- Na+/K+ ATPase Calcium Channel