ISX-9 [832115-62-5]
Cat# T2003-10mg
Size : 10mg
Marca : TargetMol
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ISX-9
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Purity:99.47%
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COA HNMR HPLC
ISX-9
Catalog No. T2003Cas No. 832115-62-5
ISX-9 (Isoxazole 9) is necessary to activate neuron-specific genes as neurogenesis inducer.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | |
|---|---|
| 2 mg | |
| 5 mg | |
| 10 mg | |
| 25 mg | |
| 50 mg | |
| 100 mg | |
| 500 mg | |
| 1 mL x 10 mM (in DMSO) |
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | ISX-9 (Isoxazole 9) is necessary to activate neuron-specific genes as neurogenesis inducer. |
| In vitro | In NSPCs, isoxazole 9 increases cell number, and promotes cell differentiation. In OPCs, isoxazole 9 induces cell damage. In outgrowth EPCs, isoxazole 9 decreases tube formation without effect on early EPCs. [1] |
| In vivo | In mice, isoxazole 9 (20 mg/kg, i.p.) crosses the BBB and increases proliferation of neuroblasts and neurogenesis via Mef2-specific mechanisms in the hippocampal SGZ. Isoxazole 9 (20 mg/kg, i.p.) also increases differentiation and dendritic complexity of immature neurons and improves memory. In MWM, isoxazole 9 improves spatial memory. [2] |
| Cell Research | Cells are treated with different concentrations of Isx-9 (0, 6.25, 12.5, 25, or 50 μM), and 2 days later, cell numbers are counted in a blinded manner to evaluate the effects of Isx-9 on the proliferation/survival of four types of progenitor/precursor cells.(Only for Reference) |
| Alias | Isoxazole 9, Isoxazole 9 (ISX-9) |
| Molecular Weight | 234.27 |
| Formula | C11H10N2O2S |
| Cas No. | 832115-62-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 11 mg/mL (47 mM) DMSO: 43 mg/mL (183.5 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/Ethanol
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg,each 
animal weighs 20 g, and the dosage volume is 100 μL. A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL.
Mother liquor preparation method: 2 mg of drug dissolved in 50 μLDMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μLDMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μLTween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify.
Dose Conversion
You can also refer to dose conversion for different animals. More
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Keywords
Mef2ISX9Isoxazole-9Ca2+Isoxazole9Ca channelsCalcium ChannelinhibitneuroDNMDAInhibitorISX-9ISX 9Ca2+ channels