Linoleic acid [60-33-3]
Cat# HY-N0729-5g
Size : 5g
Marca : MedChemExpress
Linoleic acid is a common polyunsaturated (PUFA) found in plant-based oils, nuts and seeds. Linoleic acid is a part of membrane phospholipids, and functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism .
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Linoleic acid Chemical Structure
CAS No. : 60-33-3
This product is a controlled substance and not for sale in your territory.
Based on 11 publication(s) in Google Scholar
Other Forms of Linoleic acid:
- Linoleic acid-d4 Obtenir un devis
- Linoleic acid-d11 Obtenir un devis
- Linoleic acid-13C18 Obtenir un devis
- Linoleic acid-13C1 Obtenir un devis
- Linoleic acid-d5 Obtenir un devis
- Linoleic acid-d2 Obtenir un devis
- Linoleic acid (Standard) Obtenir un devis
Description |
Linoleic acid is a common polyunsaturated (PUFA) found in plant-based oils, nuts and seeds. Linoleic acid is a part of membrane phospholipids, and functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism [1][2]. |
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Cellular Effect |
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In Vitro |
Linoleic acid contains unsaturated double bonds that are highly vulnerable to free radical attack and oxidation. If ROS are produced in great quantities, the body can no longer efficiently remove them. In such instances, ROS may be released into the extracellular space, causing damage to surrounding cells and tissues. Linoleic acid is a decomposition product of a free fatty acid and has been linked to erythrocyte damage[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Essai clinique |
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Masse moléculaire |
280.45 |
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Formule |
C18H32O2 |
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CAS No. |
60-33-3 |
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Appearance |
Liquid (Density: 0.902 g/cm3) |
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Color |
Colorless to light yellow |
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SMILES |
CCCCC/C=C\C/C=C\CCCCCCCC(O)=O |
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Structure Classification |
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Initial Source |
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Livraison | Room temperature in continental US; may vary elsewhere. |
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Stockage |
-20°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen) |
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Solvant et solubilité |
In Vitro:
DMSO : 100 mg/mL (356.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) 0.1 M NaOH : 8.33 mg/mL (29.70 mM; ultrasonic and warming and adjust pH to 11 with NaOH and heat to 60°C) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Pureté et documentation |
Purity: 99.92%
SDS (393 KB)
COA (237 KB) HNMR (236 KB) RP-HPLC (190 KB) MS (67 KB) Instruction de manipulation (2659 KB) |
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Références |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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0.1 M NaOH / DMSO | 1 mM | 3.5657 mL | 17.8285 mL | 35.6570 mL | 89.1424 mL |
5 mM | 0.7131 mL | 3.5657 mL | 7.1314 mL | 17.8285 mL | |
10 mM | 0.3566 mL | 1.7828 mL | 3.5657 mL | 8.9142 mL | |
15 mM | 0.2377 mL | 1.1886 mL | 2.3771 mL | 5.9428 mL | |
20 mM | 0.1783 mL | 0.8914 mL | 1.7828 mL | 4.4571 mL | |
25 mM | 0.1426 mL | 0.7131 mL | 1.4263 mL | 3.5657 mL | |
DMSO | 30 mM | 0.1189 mL | 0.5943 mL | 1.1886 mL | 2.9714 mL |
40 mM | 0.0891 mL | 0.4457 mL | 0.8914 mL | 2.2286 mL | |
50 mM | 0.0713 mL | 0.3566 mL | 0.7131 mL | 1.7828 mL | |
60 mM | 0.0594 mL | 0.2971 mL | 0.5943 mL | 1.4857 mL | |
80 mM | 0.0446 mL | 0.2229 mL | 0.4457 mL | 1.1143 mL | |
100 mM | 0.0357 mL | 0.1783 mL | 0.3566 mL | 0.8914 mL |
Linoleic acid Related Classifications
- Metabolic Disease Cardiovascular Disease Cancer
- Cancer Metabolism and Metastasis
- Metabolic Enzyme/Protease
- Endogenous Metabolite