MLKL Human shRNA Plasmid Kit (Locus ID 197259)
Cat# TL320765
Size : 1kit
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MLKL Human shRNA Plasmid Kit (Locus ID 197259)
SKU
TL320765
MLKL - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
4 Weeks*
| Product Data | |
| Locus ID | 197259 |
|---|---|
| Synonyms | hMLKL |
| Vector | pGFP-C-shLenti |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Format | Lentiviral plasmids |
| Components | MLKL - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 197259). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
| RefSeq | NM_001142497, NM_152649, NM_152649.1, NM_152649.2, NM_152649.3, NM_001142497.1, NM_001142497.2, BC028141, NM_001142497.3, NM_152649.4 |
| UniProt ID | Q8NB16 |
| Summary | This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015] |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact tech@clinisciences.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.