Mouse Monoclonal Anti-Thymidine Phosphorylase / PD-ECGF (Angiogenesis Marker) [Clone P-GF.44C]
Cat# NB-36-00128-P1ABX
Size : 100ug
Marca : Neo Biotech
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Thymidine Phosphorylase / PD-ECGF (Angiogenesis Marker) Antibody [P-GF.44C]
Applications & Dilutions
Summary
Recognizes a protein (amino acid 482) of 55kDa (in vivo 110kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic). Higher levels of serum TP/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites (e.g. 5'-deoxy-5-fluorouridine to 5-FU). High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites.
Product Properties & Targets
Functions
- May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro.
- Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
Key References
- O'Brien TS, et. al. Cancer Research, 1996, 56(20):4799-804.
- Fox SB, et. al. Journal of Pathology, 1995, 176:183-90.
- Fox SB, et. al. British Journal of Cancer, 1996, 73:275-80
PubMed Links
- https://pubmed.ncbi.nlm.nih.gov/2467210/
- https://pubmed.ncbi.nlm.nih.gov/1580101/
- https://pubmed.ncbi.nlm.nih.gov/10591208/
- https://pubmed.ncbi.nlm.nih.gov/15489334/
- https://pubmed.ncbi.nlm.nih.gov/1570012/
- https://pubmed.ncbi.nlm.nih.gov/1400349/
- https://pubmed.ncbi.nlm.nih.gov/1590793/
- https://pubmed.ncbi.nlm.nih.gov/21269460/
- https://pubmed.ncbi.nlm.nih.gov/24275569/
- https://pubmed.ncbi.nlm.nih.gov/14725767/
- https://pubmed.ncbi.nlm.nih.gov/16803458/
- https://pubmed.ncbi.nlm.nih.gov/19555658/
- https://pubmed.ncbi.nlm.nih.gov/9924029/
- https://pubmed.ncbi.nlm.nih.gov/12177387/
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