Empire Genomics' MYC/CON8 FISH probe is designed to detect MYC amplifications and deletions. The probe comes labeled in orange and green, but can be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
Gene Summary
This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]
Gene Details
Gene Symbol: MYC
Gene Name: MYC Proto-oncogene, BHLH Transcription Factor
Chromosome: CHR8: 128748314-128753680
Locus: 8q24.21