p53 (E-5)
Cat# sc-74573
Size : 200µg/ml
Marca : Santa Cruz Biotechnology
Contatta il distributore locale :
Telefono : +1 850 650 7790
Anticorps p53 (E-5): sc-74573
- L'Anticorps p53 (E-5) est un monoclonal de souris IgG2a κ, cité dans 3 publications, fourni en 200 µg/ml
- dirigé contre les acides aminés 186-385 de p53 d'origine Drosophila melanogaster
- recommandé pour la détection de p53 d'origine d par WB, IP, IF et ELISA
- m-IgG Fc BP-HRP et 2a BP-HRP">m-IgG2a BP-HRP sont les réactifs secondaires recommandés pour la détection de l'anticorps p53 (E-5) pour des applications de WB. Ces réactifs sont maintenant proposés en kit avec l'anticorps p53 (E-5) ().
ACCÈS RAPIDE AUX LIENS
Inhibiteurs ou p53 Activateurs pour l'analyse fonctionnelle des réponses cellulaires de p53
p53, a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation, and cell cycle control mechanisms. p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator, MDM2. MDM2 is an E3 ubiquitin ligase that is upregulated in the presence of active p53, where it poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active DNA-binding conformations and is differentially activated through posttranslational modifications, including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) of p53, amino acids 110-286, can compromise energetically-favorable association with cis elements and are implicated in several human cancers.
Séquence totale de la protéine p53 avec la séquence immunogène surlignée:
L'anticorps p53 préféré est l'Anticorps p53 (DO-1): sc-126.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps p53 (E-5) | sc-74573 | 200 µg/ml | .00 | |||
p53 (E-5): m-IgG Fc BP-HRP Kit | sc-539549 | 200 µg Ab; 10 µg BP | .00 | |||
p53 (E-5): m-IgG2a BP-HRP Kit | sc-546732 | 200 µg Ab; 10 µg BP | .00 |
What is the recommended starting dilution for Western blot for sc-74573: p53 (E-5) monoclonal antibody?
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