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> Polymyxin B [1404-26-8]

Polymyxin B [1404-26-8]

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Polymyxin B is an antibiotic. Polymyxin B inhibits Gram-negative infections by binding to the LPS of the bacterial wall with high affinity. Polymyxin B neutralizes the effect of endotoxin. Polymyxin B induces bacterial death by increasing its permeability. Polymyxin B is used in endotoxemia research.

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Polymyxin B Chemical Structure

Polymyxin B Chemical Structure

CAS No. : 1404-26-8

This product is a controlled substance and not for sale in your territory.

Based on 10 publication(s) in Google Scholar

Other Forms of Polymyxin B:

  • Polymyxin B Sulfate In-stock

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam
Description

Polymyxin B is an antibiotic. Polymyxin B inhibits Gram-negative infections by binding to the LPS of the bacterial wall with high affinity. Polymyxin B neutralizes the effect of endotoxin. Polymyxin B induces bacterial death by increasing its permeability. Polymyxin B is used in endotoxemia research[1][3].

In Vitro

Polymyxin B (10 μg/mL, 6 h) decreases the TNF-α and IL-10 production in Human peripheral blood mononuclear cells (PBMC) [3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Polymyxin B Related Antibodies
In Vivo

Polymyxin B (5-20 mg/kg for i.v; once daily for seven days) reaches the nephrotoxicity endpoint at 20 mg/kg instead of 5 mg/kg in Sprague-Dawley rats model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
CAS No.

1404-26-8
Appearance

Solid

Color

White to light yellow

SMILES

[Polymyxin B]
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvant et solubilité
In Vitro: 

H2O : 33.33 mg/mL (ultrasonic and adjust pH to 2 with HCl)

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Pureté et documentation

Purity: ≥91.0%

SDS (251 KB)

COA (243 KB)

Instruction de manipulation (2659 KB)
Références

  • [1]. Martin EL, et al. Endotoxin removal: how far from the evidence? The EUPHAS 2 Project. Contrib Nephrol. 2010;167:119-125.  [Content Brief]

    [2]. Manchandani P, et al.Role of Renal Drug Exposure in Polymyxin B-Induced Nephrotoxicity. Antimicrob Agents Chemother. 2017 Mar 24;61(4):e02391-16.  [Content Brief]

    [3]. Cardoso LS, et al.Polymyxin B as inhibitor of LPS contamination of Schistosoma mansoni recombinant proteins in human cytokine analysis. Microb Cell Fact. 2007 Jan 3;6:1.  [Content Brief]

  • [1]. Martin EL, et al. Endotoxin removal: how far from the evidence? The EUPHAS 2 Project. Contrib Nephrol. 2010;167:119-125.

    [2]. Manchandani P, et al.Role of Renal Drug Exposure in Polymyxin B-Induced Nephrotoxicity. Antimicrob Agents Chemother. 2017 Mar 24;61(4):e02391-16.

    [3]. Cardoso LS, et al.Polymyxin B as inhibitor of LPS contamination of Schistosoma mansoni recombinant proteins in human cytokine analysis. Microb Cell Fact. 2007 Jan 3;6:1.

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Polymyxin B Related Classifications

  • Anti-infection
  • Bacterial Antibiotic
Help & FAQs

Keywords:

Polymyxin B1404-26-8BacterialAntibioticEndotoxemiaGram-negative infectionLPSNephrotoxicitySprague-Dawley ratsE. coliPBMCInhibitorinhibitorinhibit