Prednisone [53-03-2]
Cat# HY-B0214-1g
Size : 1g
Marca : MedChemExpress
Prednisone (Adasone) is a corticosteroid agent with anti-inflammatory and immunosuppressive effects that can be used to study diseases related to systemic lupus erythematosus.
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Prednisone Chemical Structure
CAS No. : 53-03-2
This product is a controlled substance and not for sale in your territory.
Based on 7 publication(s) in Google Scholar
Other Forms of Prednisone:
- Prednisone-d8 In-stock
- Prednisone acetate In-stock
- Prednisone (Standard) Obtenir un devis
- Prednisone-d4 Obtenir un devis
Description |
Prednisone (Adasone) is a corticosteroid agent with anti-inflammatory and immunosuppressive effects that can be used to study diseases related to systemic lupus erythematosus[1][2]. |
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In Vivo |
Prednisone (intramuscular injection, 10 mg/kg once a day, on days 4 to 13) reduces the survival rate on days lower than the control group in BALB/c mice with encephalomyocarditis virus myocarditis. Besides, myocardial virus titers reaches a maximum on day 4, but there is no antibody titer, and on day 8 virus titers remains elevated and antibody titers is also high. On day 10, antibody titers are significantly lower than controls, while viral titers remains significantly elevated[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Essai clinique |
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Masse moléculaire |
358.43 |
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Formule |
C21H26O5 |
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CAS No. |
53-03-2 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
C[C@@]1(C2)[C@](C(CO)=O)(O)CC[C@@]1(21)[C@]3(21)CCC4=CC(C=C[C@]4(C)[C@@]3(21)C2=O)=O |
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Livraison | Room temperature in continental US; may vary elsewhere. |
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Stockage |
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Solvant et solubilité |
In Vitro:
DMSO : 125 mg/mL (348.74 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) H2O : 1 mg/mL (2.79 mM; ultrasonic and warming and heat to 80°C) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Pureté et documentation | |||||||||||||
Références |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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H2O / DMSO | 1 mM | 2.7899 mL | 13.9497 mL | 27.8995 mL | 69.7486 mL |
DMSO | 5 mM | 0.5580 mL | 2.7899 mL | 5.5799 mL | 13.9497 mL |
10 mM | 0.2790 mL | 1.3950 mL | 2.7899 mL | 6.9749 mL | |
15 mM | 0.1860 mL | 0.9300 mL | 1.8600 mL | 4.6499 mL | |
20 mM | 0.1395 mL | 0.6975 mL | 1.3950 mL | 3.4874 mL | |
25 mM | 0.1116 mL | 0.5580 mL | 1.1160 mL | 2.7899 mL | |
30 mM | 0.0930 mL | 0.4650 mL | 0.9300 mL | 2.3250 mL | |
40 mM | 0.0697 mL | 0.3487 mL | 0.6975 mL | 1.7437 mL | |
50 mM | 0.0558 mL | 0.2790 mL | 0.5580 mL | 1.3950 mL | |
60 mM | 0.0465 mL | 0.2325 mL | 0.4650 mL | 1.1625 mL | |
80 mM | 0.0349 mL | 0.1744 mL | 0.3487 mL | 0.8719 mL | |
100 mM | 0.0279 mL | 0.1395 mL | 0.2790 mL | 0.6975 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Prednisone Related Classifications
- Inflammation/Immunology Endocrinology Cancer
- Cancer Immunotherapy Cancer Metabolism and Metastasis
- Immunology/Inflammation Vitamin D Related/Nuclear Receptor Apoptosis
- Glucocorticoid Receptor Apoptosis