Recombinant Mouse Monoclonal Anti-CD20 / MS4A1 (B-Cell Marker) [Clone rIGEL/773]
Cat# NB-36-00950-P0
Size : 20ug
Marca : Neo Biotech
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Recombinant CD20/ MS4A1 (B-Cell Marker) Antibody [rIGEL/773]
CD20 Antibody in Western Blot (WB)
Applications & Dilutions
Summary
Recognizes a protein of 30-33kDa, which is identified as CD20. It is a non-Ig differentiation antigen of B-cells and its expression is restricted to normal and neoplastic B-cells, being absent from all other leukocytes and tissues. CD20 is expressed by pre-B-cells and persists during all stages of B-cell maturation but is lost upon terminal differentiation into plasma cells. This MAb can be used for immunophenotyping of leukemia and malignant cells, B lymphocyte detection in peripheral blood and B cell localization in tissues. It reacts with the majority of B-cells present in peripheral blood and lymphoid tissues and their derived lymphomas. In lymphoid tissue, germinal center blasts and B-immunoblasts are particularly reactive. It is a reliable antibody for ascribing a B-cell phenotype in known lymphoid tissues. Rarely, CD20-positive T-cell lymphomas have been reported. Reactivity has also been noted with Reed-Sternberg cells in cases of Hodgkin s disease, particularly of lymphocyte predominant type.
Product Properties & Targets
Functions
- B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes (PubMed:3925015, PubMed:7684739, PubMed:12920111). Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR (PubMed:7684739, PubMed:12920111, PubMed:18474602).
Key References
- Tedder, T.F., et al. 1994. CD20: a regulator of cell-cycle progression of B lymphocytes. Immunol. Today 15: 450-454.
PubMed Links
- https://pubmed.ncbi.nlm.nih.gov/3260267/
- https://pubmed.ncbi.nlm.nih.gov/2448768/
- https://pubmed.ncbi.nlm.nih.gov/2456210/
- https://pubmed.ncbi.nlm.nih.gov/2466899/
- https://pubmed.ncbi.nlm.nih.gov/14702039/
- https://pubmed.ncbi.nlm.nih.gov/16554811/
- https://pubmed.ncbi.nlm.nih.gov/15489334/
- https://pubmed.ncbi.nlm.nih.gov/3925015/
- https://pubmed.ncbi.nlm.nih.gov/2472394/
- https://pubmed.ncbi.nlm.nih.gov/7684739/
- https://pubmed.ncbi.nlm.nih.gov/12920111/
- https://pubmed.ncbi.nlm.nih.gov/16785532/
- https://pubmed.ncbi.nlm.nih.gov/19367720/
- https://pubmed.ncbi.nlm.nih.gov/18474602/
- https://pubmed.ncbi.nlm.nih.gov/20038800/
- https://pubmed.ncbi.nlm.nih.gov/22615937/
- https://pubmed.ncbi.nlm.nih.gov/17395584/
- https://pubmed.ncbi.nlm.nih.gov/18346788/
- https://pubmed.ncbi.nlm.nih.gov/21444918/
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