REG1A (ICRF, Islet Cells regeneration Factor, Islet of Langerhans regenerating Protein, Lithostathine 1 beta, Lithostathine-1-alpha, P19, Pancreatic stone Protein 2, Pancreatic stone Protein, Pancreatic thread Protein, PSP, PSPS, PSPS1, PSPS2, PTP, REG 1 beta, REG, REG-1-alpha, REG1A, REG1A_HUMAN, REG1B, Regenerating Islet derived Protein 1 beta, Regenerating Islet-derived Protein 1-alpha, Regenerating Protein I alpha, REGL)

The regeneration (Reg) family consists of secretory proteins involved in liver, pancreatic, gastric and intestinal cell proliferation or differentiation. Members of the REG family are divided into four subclasses, designated types I, II, III and IV. They have been implicated in the regulation of cell growth, tumorigenesis and the progression of cancer. Reg Ialpha (regenerating islet-derived I alpha), also known as Lithostathine-1alpha, PSPS, REG, P19 or PTP, is a 166 amino acid protein that contains one C-type lectin domain and belongs to the Reg family of secretory proteins. Expressed at high levels in pancreas and fetal brain and at lower levels in adult brain, Reg Ialpha is thought to inhibit spontaneous calcium carbonate precipitation and may also be associated with regeneration of brain and pancreas tissue, as well as with neuronal sprouting. The gene encoding Reg Ialpha is tandemly clustered with other Reg proteins on a region of human chromosome 2, suggesting that several Reg proteins may have arisen from a gene duplication event.||Applications: |Suitable for use in Western Blot, Immunohistochemistry. Other applications not tested.||Recommended Dilution:|Western Blot: 1:500-1:2000|Immunohistochemistry: 1:50-1:200|Optimal dilutions to be determined by the researcher.||Storage and Stability:|May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.