General Info
| Applications: | WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | SOX10 Positive Control for STJ503090 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: | WB: 1:500 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Information
| Gene Symbol: | SOX10 |
| Gene ID: | 6663 |
| Uniprot ID: | SOX10_HUMAN |
| Specificity: | This is positive control is recommended for use in combination with SOX10 antibody STJ503090. |
Description
| Tissue Specificity | Expressed in fetal brain and in adult brain, heart, small intestine and colon. |
| Function | Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3. Transcriptional activator of MBP, via binding to the gene promoter. |
| Peptide Name | Transcription Factor Sox-10 |
| Database Links | Reactome: R-HSA-9619665Reactome: R-HSA-9764302 |
| Cellular Localisation | CytoplasmNucleusMitochondrion Outer MembranePeripheral Membrane ProteinCytoplasmic Side |
| Alternative Peptide Names | Transcription Factor Sox-10 proteinSOX10 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance