VX-702 [745833-23-2]
Cat# HY-10401-200mg
Size : 200mg
Marca : MedChemExpress
VX-702 is a highly selective inhibitor of p38α MAPK, 14-fold higher potency against the p38α versus p38β.
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VX-702 Chemical Structure
CAS No. : 745833-23-2
This product is a controlled substance and not for sale in your territory.
Based on 3 publication(s) in Google Scholar
Description |
VX-702 is a highly selective inhibitor of p38α MAPK, 14-fold higher potency against the p38α versus p38β[1]. |
IC50 & Target |
p38α MAPK[1] |
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In Vitro |
Pre-incubation of platelets with VX-702 (1 μM) completely or partially inhibits p38 activation (IC50 4 to 20 nM) induced by platelet agonists including thrombin, SFLLRN, AYPGKF, U46619 and collagen. VX-702 shows no effect on platelet aggregation induced by any of the p38 MAPK agonists in the presence or absence of anti-platelet therapies[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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In Vivo |
The half-life of VX-702 is 16 to 20 hours, with a median clearance of 3.75 L/h and a volume of distribution of 73 L/kg. Both AUC and Cmax values are dose proportional for VX-702, which is predominantly cleared renally[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Essai clinique |
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Masse moléculaire |
404.32 |
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Formule |
C19H12F4N4O2 |
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CAS No. |
745833-23-2 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
O=C(N)C1=CC=C(N=C1C2=CC=C(C=C2F)F)N(C3=C(C=CC=C3F)F)C(N)=O |
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Livraison | Room temperature in continental US; may vary elsewhere. |
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Stockage |
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Solvant et solubilité |
In Vitro:
DMSO : ≥ 42 mg/mL (103.88 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) *"≥" means soluble, but saturation unknown. Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Pureté et documentation | |||||||||||||
Références |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 2.4733 mL | 12.3664 mL | 24.7329 mL | 61.8322 mL |
5 mM | 0.4947 mL | 2.4733 mL | 4.9466 mL | 12.3664 mL | |
10 mM | 0.2473 mL | 1.2366 mL | 2.4733 mL | 6.1832 mL | |
15 mM | 0.1649 mL | 0.8244 mL | 1.6489 mL | 4.1221 mL | |
20 mM | 0.1237 mL | 0.6183 mL | 1.2366 mL | 3.0916 mL | |
25 mM | 0.0989 mL | 0.4947 mL | 0.9893 mL | 2.4733 mL | |
30 mM | 0.0824 mL | 0.4122 mL | 0.8244 mL | 2.0611 mL | |
40 mM | 0.0618 mL | 0.3092 mL | 0.6183 mL | 1.5458 mL | |
50 mM | 0.0495 mL | 0.2473 mL | 0.4947 mL | 1.2366 mL | |
60 mM | 0.0412 mL | 0.2061 mL | 0.4122 mL | 1.0305 mL | |
80 mM | 0.0309 mL | 0.1546 mL | 0.3092 mL | 0.7729 mL | |
100 mM | 0.0247 mL | 0.1237 mL | 0.2473 mL | 0.6183 mL |