West Nile Virus NS3 Protease

Product Description

West Nile Virus NS3 Protease
Catalog number: B2011268
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 5 µg
Molecular Weight or Concentration: 32 kDa
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -80 °C
Keywords: WNV Protease NS3
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Voss S, Nitsche C. Targeting the protease of West Nile virus RSC Med Chem. 2021 May 26;12(8):1262-1272.
2: Chappell KJ, Stoermer MJ, Fairlie DP, Young PR. West Nile Virus_NS2B/NS3 protease as an antiviral target Curr Med Chem. 2008;15(27):2771-84.
3: Skoreński M, Milewska A, Pyrć K, Sieńczyk M, Oleksyszyn J. Phosphonate inhibitors of West Nile virus NS2B/NS3 protease J Enzyme Inhib Med Chem. 2019 Dec;34(1):8-14.
4: Tseng AC, Nerurkar VR, Neupane KR, Kae H, Kaufusi PH. Potential Dual Role of West Nile Virus_NS2B in Orchestrating NS3 Enzymatic Activity in Viral Replication Viruses. 2021 Jan 31;13(2):216.
5: Akaberi D, Båhlström A, Chinthakindi PK, Nyman T, Sandström A, Järhult JD, Palanisamy N, Lundkvist Å, Lennerstrand J. Targeting the NS2B-NS3 protease of tick-borne encephalitis virus with pan-flaviviral protease inhibitors Antiviral Res. 2021 Jun;190:105074.
6: Dražić T, Kopf S, Corridan J, Leuthold MM, Bertoša B, Klein CD. Peptide-β-lactam Inhibitors of Dengue and West Nile Virus_NS2B-NS3 Protease Display Two Distinct Binding Modes J Med Chem. 2020 Jan 9;63(1):140-156.
7: Gayen S, Chen AS, Huang Q, Kang C. West Nile Virus (WNV) protease and membrane interactions revealed by NMR spectroscopy Biochem Biophys Res Commun. 2012 Jul 13;423(4):799-804.
8: Kouretova J, Hammamy MZ, Epp A, Hardes K, Kallis S, Zhang L, Hilgenfeld R, Bartenschlager R, Steinmetzer T. Effects of NS2B-NS3 protease and furin inhibition on West Nile and Dengue virus replication J Enzyme Inhib Med Chem. 2017 Dec;32(1):712-721.
9: Rut W, Groborz K, Zhang L, Modrzycka S, Poreba M, Hilgenfeld R, Drag M. Profiling of flaviviral NS2B-NS3 protease specificity provides a structural basis for the development of selective chemical tools that differentiate Dengue from Zika and West Nile viruses Antiviral Res. 2020 Mar;175:104731.
10: Martinez AA, Espinosa BA, Adamek RN, Thomas BA, Chau J, Gonzalez E, Keppetipola N, Salzameda NT. Breathing new life into West Nile virus therapeutics; discovery and study of zafirlukast as an NS2B-NS3 protease inhibitor Eur J Med Chem. 2018 Sep 5;157:1202-1213.

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