General Info
| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Hamster |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Phospholipid-transporting ATPase ABCA1 (1112-1180 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
| Gene Symbol: | ABCA1 |
| Gene ID: | 19 |
| Uniprot ID: | ABCA1_HUMAN |
| Immunogen Region: | 1112-1180 aa |
| Specificity: | ABCA1 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from part of the human protein at the amino acid range 1112-1180 |
Description
| Post Translational Modifications | Phosphorylation on Ser-2054 regulates phospholipid efflux. Palmitoylated by ZDHHC8. Palmitoylation is essential for localization to the plasma membrane. |
| Function | Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP. Thereby, participates in phospholipid transfer to apolipoproteins to form nascent high density lipoproteins/HDLs. Transports preferentially phosphatidylcholine over phosphatidylserine. May play a similar role in the efflux of intracellular cholesterol to apolipoproteins and the formation of nascent high density lipoproteins/HDLs. Translocates phospholipids from the outer face of the plasma membrane and forces it through its gateway and annulus into an elongated hydrophobic tunnel in its extracellular domain. |
| Protein Name | Phospholipid-Transporting Atpase Abca1Atp-Binding Cassette Sub-Family A Member 1Atp-Binding Cassette Transporter 1Abc-1Atp-Binding Cassette 1Cholesterol Efflux Regulatory Protein |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-5682113Reactome: R-HSA-8963896Reactome: R-HSA-9029569 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndosome |
| Alternative Antibody Names | Anti-Phospholipid-Transporting Atpase Abca1 antibodyAnti-Atp-Binding Cassette Sub-Family A Member 1 antibodyAnti-Atp-Binding Cassette Transporter 1 antibodyAnti-Abc-1 antibodyAnti-Atp-Binding Cassette 1 antibodyAnti-Cholesterol Efflux Regulatory Protein antibodyAnti-ABCA1 antibodyAnti-ABC1 antibodyAnti-CERP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance