General Info
| Host: | Rabbit |
| Applications: | CM/ELISA/ICC/IF/IHC/IP/WB |
| Reactivity: | Human/Mouse/Pig/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-AQP11 (140-190) is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Biotin |
| Isotype: | IgG |
| Purification: | Affinity Purified |
| Concentration: | 0.57-0.67 µg/µl |
| Dilution Range: | WB: 1:500ELISA: 1:10, 000IP: 1:200IHC: 1:500ICC: 1:50IF: 1:50 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Information
| Gene Symbol: | Aqp11 |
| Gene ID: | 286758 |
| Uniprot ID: | AQP11_RAT |
| Immunogen Region: | 140-190 |
| Immunogen: | Synthetic peptide taken within amino acid region 140-190 on Aquaporin 11 protein. |
Description
| Tissue Specificity | Expressed in retina specifically at retinal Mueller glial cells. Expressed in adult testis, in the elongated spermatids (ES) and in residual bodies inside Sertoli cells. |
| Post Translational Modifications | Not glycosylated. |
| Function | Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver, kidney and brain. In situation of stress, participates in endoplasmic reticulum (ER) homeostasis by regulating redox homeostasis through the transport of hydrogen peroxide across the endoplasmic reticulum membrane thereby regulating the oxidative stress through the NADPH oxidase 2 pathway. Plays a role by maintaining an environment suitable for translation or protein foldings in the ER lumen namely by participating in the PKD1 glycosylation processing resulting in regulation of PKD1 membrane trafficking thereby preventing the accumulation of unfolding protein in ER. Plays a role in the proximal tubule function by regulating its endosomal acidification. May play a role in postnatal kidney development. |
| Protein Name | Aquaporin-11Aqp-11 |
| Database Links | Reactome: R-RNO-432047 |
| Cellular Localisation | Cytoplasmic Vesicle MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum MembraneCell MembraneCytoplasmPerinuclear RegionLocalizes Mainly To The Periphery Of Lipid DropletsIt Accumulates Partly In Mitochondrial-Associated Endoplasmic Reticulum Membranes |
| Alternative Antibody Names | Anti-Aquaporin-11 antibodyAnti-Aqp-11 antibodyAnti-Aqp11 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance