• SKU DIA-SY1-OD
    Species Reactivity

    Human
    Host Species

    Mouse
    Isotype

    IgG1/k
    Clone

    JASY1
    Clonality (Mono-/Polyclonal)

    monoclonal
    Application

    ELISA, Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections)
    Conjugation

    unconjugated
    Dilution

    Immunohistochemistry (IHC): 1:100 – 1:400
    Format

    < 0.1% NaN3, 1% BSA, concentrate, in Tris buffer (pH 7.3-7.7), ProteinA/G purified antibody
    Intended Use

    for In vitro Diagnostic Use
    Temperature - Storage

    2-8°C
    Temperature - Transport

    cooled
    Manufacturer / Brand

    dianova
    Uniprot_ID

    P18827
    Gene_ID

    6382
    Alias

    CD138, SDC, SDC1, SYND1, Syndecan 1, Syndecan Proteoglycan 1, Syndecan-1
  • Cluster of differentiation 138 (CD138), also known as Syndecan-1, is a transmembrane glycoprotein, (heparin sulphate proteoglycan) expressed on the surface of plasma cells within the hematopoetic system and on the surface of mature epithelial cells. CD138 is composed of a single chain transmembrane core protein (30,5 KDa, comprising a short cytoplasmic domain, a transmembrane domain, and a long extracellular domain) and five covalently attached glycosaminoglycan.

    In diagnostic surgical pathology, antibodies against CD138 are commonly used to identify and quantitate plasma cells. Syndecan-1 (CD138) is a cell surface protein with relevance for cell-cell and cell-matrix interaction. In normal tissues, CD138 is expressed on plasma cells but also in various epithelial cell types. CD138 is also expressed in various cancers. In several tumor types CD138 expression levels were described to be prognostically relevant. CD138 expression in cancer is of potential clinical interest. Antibody-based drugs targeting CD138 in plasmocytomas are being evaluated in clinical trials. In preclinical studies, anti-CD138 antibodies were also effective against triple negative breast cancer and melanoma cells.