General Info
| Host: | Rabbit |
| Applications: | WB/IP |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-IDH1 (1-414) is suitable for use in Western Blot and Immunoprecipitation research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000IP 1:50-1:100 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
| Gene Symbol: | IDH1 |
| Gene ID: | 3417 |
| Uniprot ID: | IDHC_HUMAN |
| Immunogen Region: | 1-414 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-414 of human IDH1 (NP_005887.2). |
| Immunogen Sequence: | MSKKISGGSVVEMQGDEMTR IIWELIKEKLIFPYVELDLH SYDLGIENRDATNDQVTKDA AEAIKKHNVGVKCATITPDE KRVEEFKLKQMWKSPNGTIR NILGGTVFREAIICKNIPRL VSGWVKPIIIGRHAYGDQYR ATDFVVPGPGKVEITYTPSD GTQKVTYLVHNFEEGGGVAM GMYNQDKSIEDFAHSSFQMA LSKGWPLYLSTKNTILKKYD GRFKDIFQEIYDKQYKSQF |
Description
| Post Translational Modifications | Acetylation at Lys-374 dramatically reduces catalytic activity. |
| Function | Catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase. Plays a critical role in the generation of NADPH, an important cofactor in many biosynthesis pathways. May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency. |
| Protein Name | Isocitrate Dehydrogenase Nadp CytoplasmicIdhIdh1Cytosolic Nadp-Isocitrate DehydrogenaseIdpcNadp(+-Specific IcdhOxalosuccinate Decarboxylase |
| Database Links | Reactome: R-HSA-2978092Reactome: R-HSA-389542Reactome: R-HSA-6798695Reactome: R-HSA-9033241Reactome: R-HSA-9818025 |
| Cellular Localisation | CytoplasmCytosolPeroxisome |
| Alternative Antibody Names | Anti-Isocitrate Dehydrogenase Nadp Cytoplasmic antibodyAnti-Idh antibodyAnti-Idh1 antibodyAnti-Cytosolic Nadp-Isocitrate Dehydrogenase antibodyAnti-Idpc antibodyAnti-Nadp(+-Specific Icdh antibodyAnti-Oxalosuccinate Decarboxylase antibodyAnti-IDH1 antibodyAnti-PICD antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance