General Info
| Host: | Rabbit |
| Applications: | IHC-P |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit monoclonal antibody anti-Myelin basic protein (150-250aa) is suitable for use in Immunohistochemistry research applications. |
| Clonality: | Monoclonal |
| Clone ID: | ZR109 |
| Conjugation: | Unconjugated |
| Isotype: | Rabbit IgG |
| Formulation: | Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin |
| Purification: | Affinity purified |
| Dilution Range: | 1:100‐200 |
| Storage Instruction: | Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C. |
Information
| Gene Symbol: | PRG2 |
| Gene ID: | 5553 |
| Uniprot ID: | PRG2_HUMAN |
| Immunogen Region: | 150-250aa |
| Specificity: | Positive control: Brain |
| Immunogen: | Recombinant fragment (around aa 150-250) of human MBP |
Description
| Tissue Specificity | Detected in plasma and urine (at protein level). Detected in placenta (at protein level). High levels of the proform in placenta and pregnancy serum.in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon. |
| Post Translational Modifications | Nitrated. |
| Function | Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA. |
| Protein Name | Bone Marrow ProteoglycanBmpgProteoglycan 2 Cleaved Into - Eosinophil Granule Major Basic ProteinEmbpMbpPregnancy-Associated Major Basic Protein |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Bone Marrow Proteoglycan: SecretedThe Proform Is SecretedEosinophil Granule Major Basic Protein: Cytoplasmic VesicleSecretory VesicleThe Mature Protein Is Found In The Matrix Of The Eosinophil's Large Specific Granule (Crystalloid Core) |
| Alternative Antibody Names | Anti-Bone Marrow Proteoglycan antibodyAnti-Bmpg antibodyAnti-Proteoglycan 2 Cleaved Into - Eosinophil Granule Major Basic Protein antibodyAnti-Embp antibodyAnti-Mbp antibodyAnti-Pregnancy-Associated Major Basic Protein antibodyAnti-PRG2 antibodyAnti-MBP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
