Enarodustat [1262132-81-9]
Cat# HY-109057-5mg
Size : 5mg
Marca : MedChemExpress
Enarodustat is a potent and orally active hypoxia-inducible factor prolyl hydroxylase inhibitor, with an EC50 of 0.22 μM. Enarodustat has the potential for renal anemia treatment.
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Enarodustat Chemical Structure
CAS No. : 1262132-81-9
This product is a controlled substance and not for sale in your territory.
Based on 2 publication(s) in Google Scholar
Other Forms of Enarodustat:
- Enarodustat hydrochloride Obtenir un devis
Description |
Enarodustat is a potent and orally active hypoxia-inducible factor prolyl hydroxylase inhibitor, with an EC50 of 0.22 μM. Enarodustat has the potential for renal anemia treatment. |
IC50 & Target |
EC50: 0.22 μM (factor prolyl hydroxylase)[1] |
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In Vitro |
Enarodustat (JTZ-951) is a potent and orally active hypoxia-inducible factor prolyl hydroxylase inhibitor, with an EC50 of 0.22 μM. Enarodustat exhibits neither CYP (IC50 > 100 μM; CYP3A4/5, CYP2C9, CYP2D6, CYP1A2, CYP2A6, CYP2C19, CYP2C8, CYP2B6) nor hERG (IC50 > 100 μM) inhibition[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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In Vivo |
Enarodustat (1 and 3 mg/kg, p.o.) increases hemoglobin levels in a dose-dependent manner with daily oral dosing in rats[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Essai clinique |
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Masse moléculaire |
340.33 |
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Formule |
C17H16N4O4 |
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CAS No. |
1262132-81-9 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
O=C(C(C1=NC=NN1C(CCC2=CC=CC=C2)=C3)=C3O)NCC(O)=O |
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Livraison | Room temperature in continental US; may vary elsewhere. |
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Stockage |
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Solvant et solubilité |
In Vitro:
DMSO : 83.33 mg/mL (244.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Pureté et documentation |
Purity: 99.94% |
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Références |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 2.9383 mL | 14.6916 mL | 29.3832 mL | 73.4581 mL |
5 mM | 0.5877 mL | 2.9383 mL | 5.8766 mL | 14.6916 mL | |
10 mM | 0.2938 mL | 1.4692 mL | 2.9383 mL | 7.3458 mL | |
15 mM | 0.1959 mL | 0.9794 mL | 1.9589 mL | 4.8972 mL | |
20 mM | 0.1469 mL | 0.7346 mL | 1.4692 mL | 3.6729 mL | |
25 mM | 0.1175 mL | 0.5877 mL | 1.1753 mL | 2.9383 mL | |
30 mM | 0.0979 mL | 0.4897 mL | 0.9794 mL | 2.4486 mL | |
40 mM | 0.0735 mL | 0.3673 mL | 0.7346 mL | 1.8365 mL | |
50 mM | 0.0588 mL | 0.2938 mL | 0.5877 mL | 1.4692 mL | |
60 mM | 0.0490 mL | 0.2449 mL | 0.4897 mL | 1.2243 mL | |
80 mM | 0.0367 mL | 0.1836 mL | 0.3673 mL | 0.9182 mL | |
100 mM | 0.0294 mL | 0.1469 mL | 0.2938 mL | 0.7346 mL |