Human FZD6 (Frizzled Homolog 6) Sandwich ELISA Kit

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	FZD6
Gene ID:	8323
Uniprot ID:	FZD6_HUMAN
Sample Type:	tissue homogenates or other biological fluids.

Tissue Specificity	Detected in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, thymus, prostate, testis, ovary, small intestine and colon. In the fetus, expressed in brain, lung, liver and kidney.
Post Translational Modifications	Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.
Function	Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear.
Protein Name	Frizzled-6 Fz-6 Hfz6
Database Links	Reactome: R-HSA-373080 Reactome: R-HSA-4086398 Reactome: R-HSA-4086400 Reactome: R-HSA-4641263 Reactome: R-HSA-5340588
Cellular Localisation	Membrane Multi-Pass Membrane Protein Cell Membrane Cell Surface Apical Cell Membrane Cytoplasmic Vesicle Membrane Endoplasmic Reticulum Membrane Colocalizes With Fzd3 At The Apical Face Of Cells Localizes To The Endoplasmic Reticulum Membrane In The Presence Of Lmbr1l
Alternative ELISA Names	Frizzled-6 ELISA kit Fz-6 ELISA kit Hfz6 ELISA kit FZD6 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance