Human IL-12 ELISpot Pair, 10 x 96-well

Cat# EA101814

Size : 10x96wells

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Human IL-12 ELISpot Pair, 10 x 96-well

Specifications
Product Data
ACCN NM_002187
Assay Type Enzyme-Linked ImmunoSpot (ELISpot)
Assay Type Sandwich
Background This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008]
Components ELISpot matched antibody pairs are extensively validated and include pre-titrated capture antibody and biotinylated detection antibody. Antibodies are supplied in quantities sufficient for 10 x 96 samples.
Cross Reactivity No cross reactivity with other human cytokines
Format 10 x 96-well
Gene Symbol IL12B
Locus ID 3593
Signal Colorimetric
Species Human
Specificity Recognizes natural human IL-12. Specific to p70 heterodimer.
Target Symbol IL12B
Description Human IL-12 ELISpot Pair, 10 x 96-well
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