Mouse Dpp4 activation kit by CRISPRa
Cat# GA201121
Size : 1kit
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Mouse Dpp4 activation kit by CRISPRa
SKU
GA201121
Dpp4 CRISPRa kit - CRISPR gene activation of mouse dipeptidylpeptidase 4
2 Weeks*
| Product Data | |
| Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
|---|---|
| Target Symbol | Dpp4 |
| Locus ID | 13482 |
| Components | GA201121G1, Dpp4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA201121G2, Dpp4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA201121G3, Dpp4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
| Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
| Reference Data | |
| RefSeq | NM_001159543, NM_010074 |
| UniProt ID | P28843 |
| Synonyms | Cd26; Dpp-4; THAM |
| Summary | Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.[UniProtKB/Swiss-Prot Function] |
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| SDS |
| SKU | Description | Size | ||
|---|---|---|---|---|
| KN304781 | Dpp4 - mouse gene knockout kit via CRISPR, HDR mediated | 1 kit | | |
| KN304781BN | Dpp4 - mouse gene knockout kit via CRISPR, HDR mediated | 1 kit | | |
| KN304781LP | Dpp4 - mouse gene knockout kit via CRISPR, HDR mediated | 1 kit | | |
| KN304781RB | Dpp4 - mouse gene knockout kit via CRISPR, HDR mediated | 1 kit | | |
| KN504781 | Dpp4 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. | 1 kit | | |
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.