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> Obeticholic Acid [459789-99-2]

Obeticholic Acid [459789-99-2]

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Cat# T1789-1mL

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Obeticholic Acid

Obeticholic Acid
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Purity:99.97%
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COA HPLC HNMR

Obeticholic Acid

Catalog No. T1789Cas No. 459789-99-2
Obeticholic Acid (6-ECDCA) is a Farnesoid X Receptor Agonist. The mechanism of action of obeticholic acid is as a Farnesoid X Receptor Agonist.
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Pack Size
5 mg
10 mg
25 mg
50 mg
100 mg
200 mg
500 mg
1 mL x 10 mM (in DMSO)

Product Introduction

Bioactivity
Description
Obeticholic Acid (6-ECDCA) is a Farnesoid X Receptor Agonist. The mechanism of action of obeticholic acid is as a Farnesoid X Receptor Agonist.
AliasINT-747, 6-Ethylchenodeoxycholic acid, 6-ECDCA
Chemical Properties
Molecular Weight420.63
FormulaC26H44O4
Cas No.459789-99-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 45 mg/mL (106.98 mM)
Ethanol: 78 mg/mL (185.4 mM)
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM2.3774 mL11.8869 mL23.7739 mL118.8693 mL
5 mM0.4755 mL2.3774 mL4.7548 mL23.7739 mL
10 mM0.2377 mL1.1887 mL2.3774 mL11.8869 mL
20 mM0.1189 mL0.5943 mL1.1887 mL5.9435 mL
50 mM0.0475 mL0.2377 mL0.4755 mL2.3774 mL
100 mM0.0238 mL0.1189 mL0.2377 mL1.1887 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg,each TargetMol | Animal experiments animal weighs 20 g, and the dosage volume is 100 μL. A total of TargetMol | Animal experiments 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL.
Mother liquor preparation method: 2 mg of drug dissolved in 50 μLDMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μLDMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μLTween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify.

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

AutophagyorallyNR1H4activefarnesoidINT 747FXRObeticholic AcidreceptorInhibitorinhibitINT747