Tocilizumab [375823-41-9]
Cat# HY-P9917-5mg
Size : 5mg
Marca : MedChemExpress
Tocilizumab (Anti-Human IL6R, Humanized Antibody) is an anti-human interleukin-6 receptor (IL-6R) neutralizing antibody, prevents binding of IL-6 to the IL-6R, thereby inhibiting both classic and trans-signaling. Tocilizumab (Anti-Human IL6R, Humanized Antibody) can be used for the treatment of rheumatoid arthritis. Tocilizumab is remarkablely effective for the study of severe COVID-19 (coronavirus disease).
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Tocilizumab Chemical Structure
CAS No. : 375823-41-9
This product is a controlled substance and not for sale in your territory.
Based on 20 publication(s) in Google Scholar
Voir tous les produits spécifiques à Isoform Interleukin Related:
Human IgG1 kappa, Isotype Control
Human IgG1 kappa, Isotype Control
Human IgG1 kappa, Isotype Control
Human IgG1 kappa, Isotype Control
Human IgG1 kappa, Isotype Control
Human IgG1 kappa, Isotype Control
Human IgG1 kappa, Isotype Control
Human IgG1 kappa, Isotype Control
Human IgG1 kappa, Isotype Control
Human IgG1 kappa, Isotype Control
Human IgG1 kappa, Isotype Control
Human IgG1 kappa, Isotype Control
Human IgG1 kappa, Isotype Control
Human IgG1 kappa, Isotype Control
Human IgG1 kappa, Isotype Control
Human IgG1 kappa, Isotype Control
Description |
Tocilizumab (Anti-Human IL6R, Humanized Antibody) is an anti-human interleukin-6 receptor (IL-6R) neutralizing antibody, prevents binding of IL-6 to the IL-6R, thereby inhibiting both classic and trans-signaling. Tocilizumab (Anti-Human IL6R, Humanized Antibody) can be used for the treatment of rheumatoid arthritis[1]. Tocilizumab is remarkablely effective for the study of severe COVID-19 (coronavirus disease)[4]. |
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Isotype |
Human IgG1 kappa |
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Recommend Isotype Controls |
Human IgG1 kappa, Isotype Control |
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Species |
Humanized |
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IC50 & Target[1][2] |
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In Vitro |
Tocilizumab (Anti-Human IL6R, Humanized Antibody) (1-100 ng/mL; 24 hours, 48 hours) inhibits the cell proliferation (growth rate) in a dose-dependent manner, growth rate by HACM is reduced almost completely by 100 ng/mL tocilizumab[2]. Tocilizumab (Anti-Human IL6R, Humanized Antibody) (0.001-10,000 μg/ml; 2 days) inhibits Ba/F3-gp130-IL-6R cell proliferation stimulated with hIL-6 with an IC50 of 13.5 ng/ml[1]. Tocilizumab (Anti-Human IL6R, Humanized Antibody) (1 μM; 6 hours) reduces the phosphorylation of STAT3 in vitro consistent with in vivo SAS cells[3]. Tocilizumab (Anti-Human IL6R, Humanized Antibody) (1-5 μM; 24 hours) significantly reduces VEGF mRNA expression in SAS cells with serum-free medium[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay[2]
Cell Cytotoxicity Assay[1]
Western Blot Analysis[3]
RT-PCR[3]
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In Vivo |
Tocilizumab (Anti-Human IL6R, Humanized Antibody) (intravenous injection; 1.0 mg/100 μL; twice a week, three weeks) decreases the volume of each metastatic focus in tocilizumab-injected mouse brains[2]. Tocilizumab (Anti-Human IL6R, Humanized Antibody) (intraperitoneal injection;100 μg/mL, every 48 hours; 20days) suppresses OSCC progression and suppresses Tumor Angiogenesis[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Essai clinique |
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CAS No. |
375823-41-9 |
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Appearance |
Liquid |
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Color |
Colorless to light yellow |
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SMILES |
[Tocilizumab] |
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Livraison | Shipping with dry ice. |
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Stockage |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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Pureté et documentation |
Purity: 99.67% |
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Références |
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Tocilizumab Related Classifications
- Immunology/Inflammation
- Interleukin Related
Calculateur de molarité
Calculateur de dilution
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
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Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.
Keywords:
Tocilizumab375823-41-9Anti-Human IL6R, Humanized AntibodyInterleukin RelatedILantibodyIL-6RNeutralizingrheumatoidarthritisSARS-CoV-2coronavirus diseaserespiratory failuredyspnoeaCOVID-19Inhibitorinhibitorinhibit