Tumor necrosis factor alpha (TNFSF2) is a member of the TNF Superfamily. It is produced chiefly by activated macrophages, but it is produced also by a broad variety of cell types including lymphoid cells, mast cells, endothelial cells, cardiac myocytes, adipose tissue, fibroblasts, and neuronal tissue. The primary role of TNF-α is in the regulation of immune cells. TNF-α, being an endogenous pyrogen, is able to induce fever, to induce apoptotic cell death, to induce sepsis (through IL-1 & IL-6 production), to induce cachexia, induce inflammation, and to inhibit tumorigenesis and viral replication.

Reactivity - ELISA
Atlantic Salmon TNF-α - Strong
Bovine TNF-α - None
Canine TNF-α - None
Caprine TNF-α - Weak
Cynomolgus Monkey TNF-α - None
Dolphin TNF-α - None
Equine TNF-α - None
Feline TNF-α - None
Guinea Pig TNF-α - None
Human TNF-α - None
Mouse TNF-α - None
Ovine TNF-α - None
Rabbit TNF-α - None
Swine TNF-α - None
Zebrafish TNF-α - Strong